USP20 and ZXDB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP20	ZXDB
Description		ubiquitin specific peptidase 20	zinc finger X-linked duplicated B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Blood trace element (Zn levels) ( 23720494)
Interacting Genes		71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB	3 interacting genes: EIF4A3 USP20 ZGPAT
Entrez ID		10868	158586
HPRD ID		07505	11777
Ensembl ID		ENSG00000136878	ENSG00000198455
Uniprot IDs		Q9Y2K6	P98169
PDB IDs		6KCZ
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death	Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Negative Regulation Of Translational Elongation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity U2-type Catalytic Step 1 Spliceosome Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Stem-loop Binding Nucleic Acid Binding Poly(A) Binding Negative Regulation Of Protein Metabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Exon-exon Junction Complex Regulation Of Protein Tyrosine Kinase Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Signal Transduction Negative Regulation Of ERBB Signaling Pathway Exploration Behavior Regulation Of Signaling Receptor Activity
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