USP20 and ASCL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP20	ASCL1
Description		ubiquitin specific peptidase 20	achaete-scute family bHLH transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm	Chromatin Nucleus Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Pattern Specification Process Nervous System Development Neuroblast Fate Determination Neuroblast Proliferation Sensory Organ Development Heart Development Regulation Of Notch Signaling Pathway Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Oligodendrocyte Cell Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Neuron Fate Commitment Neuron Fate Specification Neuron Development Generation Of Neurons Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Neural Precursor Cell Proliferation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism GABAergic Neuron Differentiation Motor Neuron Migration Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Ub-specific processing proteases	NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS		Metabolite levels ( 23823483)	C-reactive protein levels ( 21300955 30388399) Menopause (age at onset) ( 26414677) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB	13 interacting genes: BMP2 EP300 HUNK MEF2A MEF2C MEF2D MTNR1A NEUROG2 RSPH1 TCF4 UBQLN1 UBQLN2 USP20
Entrez ID		10868	429
HPRD ID		07505	00011
Ensembl ID		ENSG00000136878	ENSG00000139352
Uniprot IDs		Q9Y2K6	P50553
PDB IDs		6KCZ
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death	System Development Nervous System Development Protein Dimerization Activity Heart Development DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Cardiac Chamber Formation Positive Regulation Of Neuron Differentiation Autophagosome Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Autophagosome Organization Positive Regulation Of ERAD Pathway Regulation Of Cardiac Muscle Cell Differentiation Muscle Organ Development Positive Regulation Of RNA Metabolic Process Platelet Formation Regulation Of Autophagy Histone Deacetylase Binding Muscle Structure Development Regulation Of ERAD Pathway Regulation Of Smooth Muscle Cell Proliferation Muscle Tissue Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Vacuole Organization Cardiac Muscle Cell Differentiation Animal Organ Development Cellular Developmental Process Regulation Of Neuron Differentiation Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Bone Mineralization Positive Regulation Of Ossification Cell Differentiation Cardiocyte Differentiation Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Regulation Of Transport Transcription Regulator Complex Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?