USP20 and USP28

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP20	USP28
Description		ubiquitin specific peptidase 20	ubiquitin specific peptidase 28
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases	Ub-specific processing proteases
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB	43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		10868	57646
HPRD ID		07505	15632
Ensembl ID		ENSG00000136878	ENSG00000048028
Uniprot IDs		Q9Y2K6	A0A8V8TLZ9 B4E3L3 Q96RU2
PDB IDs		6KCZ	2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death	Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?