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FBL and PRMT6
Number of citations of the paper that reports this interaction (PubMedID
16157300
)
0
Data Source:
BioGRID
(enzymatic study)
FBL
PRMT6
Description
fibrillarin
protein arginine methyltransferase 6
Image
GO Annotations
Cellular Component
Fibrillar Center
Granular Component
Nucleus
Nucleoplasm
Nucleolus
Cajal Body
Membrane
Box C/D Methylation Guide SnoRNP Complex
Small-subunit Processome
Extracellular Exosome
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
TFIID-class Transcription Factor Complex Binding
RNA Binding
Protein Binding
Methyltransferase Activity
RRNA Methyltransferase Activity
Transferase Activity
ATPase Binding
U6 SnRNA 2'-O-ribose Methyltransferase Activity
Histone H2AQ104 Methyltransferase Activity
Chromatin Binding
Protein Binding
Methyltransferase Activity
Histone Arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Transferase Activity
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Histone Binding
Histone H4R3 Methyltransferase Activity
Histone H3R2 Methyltransferase Activity
Histone H2AR3 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Biological Process
Box C/D Sno(s)RNA 3'-end Processing
Osteoblast Differentiation
Chromatin Remodeling
RRNA Processing
Sno(s)RNA Metabolic Process
RRNA Methylation
Methylation
Ribosomal Small Subunit Biogenesis
SnoRNA Localization
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Base-excision Repair
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Regulation Of Mitochondrion Organization
Methylation
Cellular Response To Stress
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of DNA-templated Transcription
Cellular Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Blood pressure measurement (low sodium intervention) (
24165912
)
Intelligence (
22449649
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Non-obstructive azoospermia (
22197933
)
Obesity (early onset extreme) (
23563609
)
Refractive error (
32231278
)
Response to SSRI in MDD or openness (
29559929
)
Restless legs syndrome (
29029846
)
Sex hormone-binding globulin levels (
22829776
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
21 interacting genes:
DDX17
DDX5
ERG
H2AC20
KLF6
MAP3K14
PIN4
PRMT1
PRMT3
PRMT6
PRMT8
PSMB6
PTEN
RUVBL1
RUVBL2
SMN1
SMN2
SNRPN
TAF9
TBC1D17
ZNF792
90 interacting genes:
AK8
AP1G2
ASB3
AUNIP
BCAT1
BLZF1
BMP3
C8orf74
CDCA4
CETN2
DCAF16
DNAJA3
DNALI1
DXO
FBL
FIP1L1
FKBP7
FYCO1
FYN
GBE1
GPS2
GRHL3
GSTCD
GTPBP2
H2AC18
H2BC21
H3-5
H3C14
H3C15
H4C16
H4C6
HESX1
HMGA1
HMGA2
HNRNPH2
HOXA1
HOXA5
HOXC4
ID2
KIAA0408
KIF9
KLHL20
LDHAL6B
LENG8
LINC02875
LOXL4
MALT1
MED28
METTL27
MLC1
MNDA
MTF2
NEFL
NOSTRIN
NR1D2
OAS1
OPA3
PABPC1
PCGF5
PELO
PEX7
PSMD11
PYCR3
PYGO1
RAC1
RAD17
RASSF2
SERGEF
SLU7
SMAD9
SMARCD1
SNF8
SPATA22
SPIN1
SPSB1
SRGAP3
SSX2IP
STARD10
SUV39H1
TDO2
TEX35
THEMIS
TMED5
TRIB2
TSC1
UBXN10
WDFY3
ZNF436
ZNF557
ZSCAN9
Entrez ID
2091
55170
HPRD ID
00617
10505
Ensembl ID
ENSG00000105202
ENSG00000198890
Uniprot IDs
P22087
Q96LA8
PDB IDs
2IPX
7MQ8
7MQ9
7MQA
7SE6
7SE7
7SE8
7SE9
7SEA
7SEB
7SEC
7SED
4HC4
4QPP
4QQK
4Y2H
4Y30
5E8R
5EGS
5HZM
5WCF
6P7I
6W6D
6WAD
7NR4
Enriched GO Terms of Interacting Partners
?
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Histone H4R3 Methyltransferase Activity
Histone Methyltransferase Activity
Box C/D SnoRNP Assembly
Nucleoplasm
Nucleus
Chromatin Remodeling
RNA Splicing
Chromatin Organization
Protein-RNA Complex Assembly
RNA Splicing, Via Transesterification Reactions
Ribonucleoprotein Complex
Nucleic Acid Metabolic Process
MLL1 Complex
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Peptidyl-arginine Methylation
R2TP Complex
Helicase Activity
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Histone H4 Methyltransferase Activity
Telomerase RNA Localization To Cajal Body
Regulation Of RNA Metabolic Process
RNA Processing
Methyltransferase Activity
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
MRNA Metabolic Process
TFIID-class Transcription Factor Complex Binding
SMN Complex
RPAP3/R2TP/prefoldin-like Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Methylation
Gemini Of Cajal Bodies
Swr1 Complex
Positive Regulation Of DNA Recombination
Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Regulation Of Double-strand Break Repair Via Homologous Recombination
ATPase Binding
Ino80 Complex
MRNA Processing
Regulation Of DNA Repair
Regulation Of DNA Strand Elongation
Protein Stabilization
SMN-Sm Protein Complex
Regulation Of Gene Expression
Dynein Axonemal Particle
Positive Regulation Of Double-strand Break Repair
Nucleus
Structural Constituent Of Chromatin
Protein Binding
Nucleosome
Nucleoplasm
Chromatin Organization
Nucleosome Organization
Chromatin Remodeling
Chromosome
Senescence-associated Heterochromatin Focus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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