FBL and PRMT6

Number of citations of the paper that reports this interaction (PMID 16157300)
14

Data Source:
BioGRID (enzymatic study)

		FBL	PRMT6
Gene Name		fibrillarin	protein arginine methyltransferase 6
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Gene Ontology Annotations	Cellular Component	Granular Component Nucleus Nucleolus Cajal Body Membrane Box C/D SnoRNP Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding Histone-glutamine Methyltransferase Activity	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Osteoblast Differentiation RRNA Processing TRNA Processing SnoRNA Metabolic Process Histone Glutamine Methylation	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		19 interactors: DDX17 DDX5 ERG KLF6 MAP3K14 NOP56 PIH1D1 PIN4 PRMT1 PRMT3 PRMT6 PSMB6 RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		2091	55170
HPRD ID		00617	10505
Ensembl ID		ENSG00000105202	ENSG00000198890
Uniprot IDs		P22087	Q96LA8
PDB IDs		2IPX	4HC4
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine RNA Metabolic Process Peptidyl-arginine N-methylation Peptidyl-amino Acid Modification Histone Arginine Methylation Peptidyl-arginine Methylation Histone Modification Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H4-R3 Methylation Cellular Protein Modification Process Histone H2A Acetylation RNA Processing Chromosome Organization Regulation Of Skeletal Muscle Cell Differentiation Histone Acetylation Histone Methylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Splicing Protein Acetylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Protein Methylation Ribonucleoprotein Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Metabolic Process NcRNA Metabolic Process Spliceosomal SnRNP Assembly Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone H4 Acetylation	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?		actinomycin character condensed contribution delays differentiation es example fibrillarin hyperdynamic interestingly knockdown latter lif lineages methyltransferase nucleolar nucleoli partial pluripotency pluripotent processing prolonged promoted proper ribosomal rrna stem unique	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		actinomycin character condensed contribution delays differentiation es example fibrillarin hyperdynamic interestingly knockdown latter lif lineages methyltransferase nucleolar nucleoli partial pluripotency pluripotent processing prolonged promoted proper ribosomal rrna stem unique	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?