PRMT6 and FYCO1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	FYCO1
Description		protein arginine methyltransferase 6	FYVE and coiled-coil domain autophagy adaptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Lysosome Endosome Late Endosome Autophagosome Golgi Apparatus Membrane Cytoplasmic Vesicle
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Autophagosome Maturation
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Bone mineral content ( 31790847) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	4 interacting genes: APP KDM1A PRMT6 RAF1
Entrez ID		55170	79443
HPRD ID		10505	06215
Ensembl ID		ENSG00000198890	ENSG00000163820
Uniprot IDs		Q96LA8	Q9BQS8
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	5CX3 5D94 7BQI
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Death-inducing Signaling Complex Assembly Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Purine-containing Compound Chromatin Remodeling Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Differentiation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cell Maturation Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon
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