PRMT6 and NR1D2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	NR1D2
Gene Name		protein arginine methyltransferase 6	nuclear receptor subfamily 1, group D, member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Core Promoter Sequence-specific DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Lipid Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Inflammatory Response Lipid Homeostasis Regulation Of Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	19 interactors: CUL1 GTF2B HDAC1 KRT40 KRTAP10-9 KRTAP4-2 MID2 NCOA5 NCOR1 NOTCH2NL NR1D1 PRMT6 RBPMS RGN SIN3B TAF6 TAF9 TRIM27 UBE2I
Entrez ID		55170	9975
HPRD ID		10505	03809
Ensembl ID		ENSG00000198890	ENSG00000174738
Uniprot IDs		Q96LA8	B4DXD3 F1D8P2 Q14995 Q6NSM0
PDB IDs		4HC4	2V0V 2V7C 3CQV
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Viral Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Viral Transcription Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Negative Regulation Of Viral Process Regulation Of Cellular Process Circadian Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Elongation Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Modification Rhythmic Process Negative Regulation Of Viral Release From Host Cell Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Receptor Biosynthetic Process Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell Histone Modification
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	adopting af2 arrangement bend bulky cavity circadian clock closing cognate conformation dimeric erb erbalpha erbbeta filled filling flexibility geometry h11 helix hydrophobic kinked lbp orphan pocket putative rev stabilize
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	adopting af2 arrangement bend bulky cavity circadian clock closing cognate conformation dimeric erb erbalpha erbbeta filled filling flexibility geometry h11 helix hydrophobic kinked lbp orphan pocket putative rev stabilize
Tagcloud (Intersection) ?