PRMT6 and LOXL4

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT6	LOXL4
Gene Name		protein arginine methyltransferase 6	lysyl oxidase-like 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Space Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Protein-lysine 6-oxidase Activity Scavenger Receptor Activity Copper Ion Binding Protein Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Receptor-mediated Endocytosis Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Collagen formation Crosslinking of collagen fibrils Elastic fibre formation Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	14 interactors: AP1M2 APOE CDC37 COL2A1 ECSIT EXOC6 KDM1A LONP1 MAST1 PRMT6 RAD23A RNF32 SUV39H1 TRIP13
Entrez ID		55170	84171
HPRD ID		10505	09538
Ensembl ID		ENSG00000198890	ENSG00000138131
Uniprot IDs		Q96LA8	Q96JB6
PDB IDs		4HC4
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Organelle Organization Protein Metabolic Process Cellular Response To Stress Response To Stress Viral Process Developmental Process Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Cellular Protein Metabolic Process Regulation Of Oxidoreductase Activity Cellular Response To DNA Damage Stimulus Cell Differentiation Regulation Of Metabolic Process Histone H3-R2 Methylation Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Histone Modification Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Chromosome Organization Cell Development DNA Metabolic Process Histone Methylation Response To Stimulus Cellular Response To Stimulus Protein Localization Cellular Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization Establishment Of Localization In Cell Maintenance Of Location In Cell Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Axon Development
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts
Tagcloud (Intersection) ?