FBL and TBC1D17

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		FBL	TBC1D17
Name		fibrillarin	TBC1 domain family member 17
Structure			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Endosome Autophagosome Cytosol Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization	Autophagy Protein Transport Retrograde Transport, Endosome To Golgi Regulation Of Cilium Assembly
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	TBC/RABGAPs
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	20 interacting genes: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1 UBC
Entrez ID		2091	79735
HPRD ID		00617	15471
Ensembl ID		ENSG00000105202	ENSG00000104946
Uniprot IDs		P22087	Q9HA65
PDB IDs		2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED	Not available
GO Terms Enriched among Interactors		Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair	Mitophagy Autophagy Autophagy Of Mitochondrion Autophagosome Melanosome Plasma Membrane To Endosome Transport Cellular Response To Nitrogen Starvation Endomembrane System Phosphatidylethanolamine Binding Macroautophagy G Protein Activity Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagosome Membrane Vacuole Organization Endocytic Vesicle GDP Binding Catabolic Process Extracellular Exosome Cytoplasmic Vesicle Ubiquitin Protein Ligase Binding Phospholipid Binding K63-linked Polyubiquitin Modification-dependent Protein Binding GTPase Activity Early Endosome Import Into Cell Microtubule Protein-containing Complex Disassembly GTP Binding Beta-tubulin Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Organelle Assembly Organelle Organization Cellular Response To Starvation Organelle Membrane Endosome Endocytosis Early Endosome Membrane Protein-macromolecule Adaptor Activity Response To Nutrient Levels Histone H2AQ104 Methyltransferase Activity JNK Cascade Glutamine Secretion Protein Localization To Phagocytic Vesicle Response To Starvation Cyclin D2-CDK4 Complex Box C/D Sno(s)RNA 3'-end Processing Intracellular Protein Transport Protein Localization To Early Endosome