FBL and KLF6

Number of citations: 56 (PubMedID 17636026)
Data Source: BioGRID (pull down)

		FBL	KLF6
Name		fibrillarin	KLF transcription factor 6
Structure			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	None
GWAS		No GWAS studies recorded	Asthma (bronchodilator response) ( 23508266 ) Coronary artery calcification ( 23870195 ) Diastolic blood pressure ( 27841878 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 33713608 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 31604244 ) Plasma anti-thyroglobulin levels ( 29678681 ) Red blood cell count ( 32888494 )
Interacting Genes		21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53
Entrez ID		2091	1316
HPRD ID		00617	03632
Ensembl ID		ENSG00000105202	ENSG00000067082
Uniprot IDs		P22087	D3GC14 Q99612
PDB IDs		2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED	Not available
GO Terms Enriched among Interactors		Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair	Pre-snoRNP Complex Histone Deacetylase Binding Nucleoplasm DNA Binding Box C/D Methylation Guide SnoRNP Complex RNA Metabolic Process Transcription Corepressor Binding Chromatin Remodeling Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Small-subunit Processome TFIID-class Transcription Factor Complex Binding Ribosomal Small Subunit Biogenesis DNA-templated Transcription Transcription Repressor Complex Box C/D SnoRNP Assembly P53 Binding Promoter-specific Chromatin Binding Regulation Of MiRNA Transcription Nucleus Chromatin Organization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II ATPase Binding RRNA Metabolic Process C2H2 Zinc Finger Domain Binding Cellular Response To Oxygen-containing Compound Low-density Lipoprotein Particle Nucleobase-containing Compound Biosynthetic Process Transcription Cis-regulatory Region Binding Histone Methyltransferase Binding Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleolus Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Negative Regulation Of Transcription By RNA Polymerase II SnoRNA Binding Nucleic Acid Metabolic Process High-density Lipoprotein Particle RRNA Transcription Regulation Of RNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription