FBL and SMN1

Number of citations of the paper that reports this interaction (PubMedID 8670859)
56

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FBL	SMN1
Description		fibrillarin	survival of motor neuron 1, telomeric
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GO Annotations	Cellular Component	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		2091	6606
HPRD ID		00617	02646
Ensembl ID		ENSG00000105202	ENSG00000172062
Uniprot IDs		P22087	B4DP61 E7EQZ4 Q16637
PDB IDs		2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED	1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair	Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding
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