PRMT6 and DCAF16

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	DCAF16
Description		protein arginine methyltransferase 6	DDB1 and CUL4 associated factor 16
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Ubiquitination
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Neddylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Birth weight ( 31043758) Height ( 34270706) Hip circumference adjusted for BMI ( 34021172) Offspring birth weight ( 31043758)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	3 interacting genes: CUL4B PRMT1 PRMT6
Entrez ID		55170	54876
HPRD ID		10505	07891
Ensembl ID		ENSG00000198890	ENSG00000163257
Uniprot IDs		Q96LA8	Q9NXF7
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	8G46 8OV6
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Regulation Of Megakaryocyte Differentiation DNA Repair DNA Metabolic Process DNA Damage Response GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Methyltransferase Activity Histone H3R2 Methyltransferase Activity Methylation Regulation Of Myeloid Cell Differentiation Histone Arginine N-methyltransferase Activity N-methyltransferase Activity Regulation Of Protein Metabolic Process Cellular Response To Stress Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4 Methyltransferase Activity Cellular Response To Methionine Cul4B-RING E3 Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Regulation Of Hemopoiesis UV-damage Excision Repair Methylosome Protein Methyltransferase Activity Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Protein Metabolic Process S-adenosyl-L-methionine Binding Chromatin Remodeling Histone H3 Methyltransferase Activity Methyl-CpG Binding Viral Protein Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of P38MAPK Cascade Cul4-RING E3 Ubiquitin Ligase Complex Astrocyte Differentiation Positive Regulation Of Protein Metabolic Process Protein Methylation Negative Regulation Of JNK Cascade Positive Regulation Of Erythrocyte Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?