PRMT6 and OAS1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	OAS1
Description		protein arginine methyltransferase 6	2'-5'-oligoadenylate synthetase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Ribosome Membrane
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Glucose Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Glucose Homeostasis Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Cellular Respiration Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs			Cysteine-S-acetamide
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Blood protein levels ( 30072576) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27
Entrez ID		55170	4938
HPRD ID		10505	08879
Ensembl ID		ENSG00000198890	ENSG00000089127
Uniprot IDs		Q96LA8	A0A6Q8PHR1 A0A7P0T8F9 A0A7P0T9Q4 A0A7P0Z4N8 H0YIB8 P00973
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	4IG8
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Protein Transport Golgi Vesicle Transport Vesicle-mediated Transport Establishment Of Protein Localization Organelle Organization Intracellular Protein Localization Centrosome Cycle Non-motile Cilium Assembly Endosomal Transport Histone H2AR3 Methyltransferase Activity Mitotic Cytokinesis Platelet Morphogenesis Structural Constituent Of Postsynapse Cytoskeleton-dependent Cytokinesis Microtubule Organizing Center Organization Establishment Of Localization In Cell Cellular Localization Negative Regulation Of Catabolic Process Retrograde Transport, Endosome To Golgi Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RRNA (guanine-N7)-methylation Negative Regulation Of Autophagy Cytoskeleton Organization Microtubule Cytoskeleton Organization Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Glycosylation Golgi Organization Identical Protein Binding Supramolecular Fiber Organization Cytosolic Transport FHF Complex Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity
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