PRMT6 and SPIN1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	SPIN1
Description		protein arginine methyltransferase 6	spindlin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Chromatin Nucleus Nucleoplasm Nucleolus Spindle Cytosol Nuclear Membrane
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Protein Binding Histone H3K4me3 Reader Activity Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Chromatin Organization Regulation Of DNA-templated Transcription Gamete Generation RRNA Transcription Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle Protein Localization To Chromatin Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Height ( 18391951 20881960 31562340) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	5 interacting genes: HMGB1 HSPB1 PRMT6 PTN RPL5
Entrez ID		55170	10927
HPRD ID		10505	18096
Ensembl ID		ENSG00000198890	ENSG00000106723
Uniprot IDs		Q96LA8	Q9Y657
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	2NS2 4H75 4MZF 4MZG 4MZH 5JSG 5JSJ 5Y5W 6I8B 6I8L 6I8Y 6QPL 7BQZ 7BU9 7CNA 7E9M 7EA1 7OCB 8GTX
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Positive Regulation Of Chemotaxis Regulation Of Endothelial Cell Migration Regulation Of Chemotaxis Base-excision Repair Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Catalytic Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Hemopoiesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Protein Kinase C Signaling Dendrite Regeneration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Leukocyte Chemotaxis C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Protein Kinase C Inhibitor Activity Ossification Involved In Bone Remodeling Negative Regulation Of Proteolysis GABA Receptor Complex Histone Arginine N-methyltransferase Activity Integrin Binding Positive Regulation Of Leukocyte Migration Negative Regulation Of Catalytic Activity Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation
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