PRMT6 and SSX2IP

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT6	SSX2IP
Gene Name		protein arginine methyltransferase 6	synovial sarcoma, X breakpoint 2 interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cell-cell Adherens Junction Cell Leading Edge Centriolar Satellite Ciliary Basal Body Protein Complex
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Protein Binding Protein Domain Specific Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Cell Adhesion Regulation Of Rac Protein Signal Transduction Intraciliary Transport Involved In Cilium Morphogenesis Cilium Assembly Centrosome Organization Regulation Of Cell Motility
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	89 interactors: ABLIM3 ACTN1 ACTN2 AEN AP1M1 ARNT2 BEX2 BRCA1 BYSL C11orf54 C14orf105 C19orf66 C20orf195 CARD9 CCHCR1 CCNH CDC23 CDC42 CDCA7L CEP55 CHCHD3 DAXX DRG1 EHHADH EIF4A2 FAM124B FAM161A FAM214A FAM64A FANCL FBF1 FRMD6 GEM GOLGA8F IKBKG INO80B KAT5 KDM1A KIF9 KLHL42 KRT15 KRT31 KRT40 KRTAP10-7 LATS1 LMO2 MFAP1 MLLT4 MORN4 MOS MRPL53 NAA10 NDN NOL12 PHC2 PKN1 POLL PRKAA1 PRMT6 PRPF31 PSMA1 SCNM1 SSX2 SSX3 SYT17 TBP TEAD4 TFIP11 TOP3B TP53BP2 TRIM37 TRIM42 TRIM54 TTC23 WDR5 XIAP YWHAQ YWHAZ ZBTB24 ZGPAT ZMAT2 ZNF124 ZNF250 ZNF3 ZNF417 ZNF587 ZNF792 ZRSR2 ZSCAN12
Entrez ID		55170	117178
HPRD ID		10505	10566
Ensembl ID		ENSG00000198890	ENSG00000117155
Uniprot IDs		Q96LA8	B7ZB07 Q9Y2D8
PDB IDs		4HC4
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organelle Organization Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Chromosome Organization Biosynthetic Process Regulation Of Metabolic Process Signal Transduction By P53 Class Mediator Cellular Process Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Histone H3-K4 Methylation Regulation Of Apoptotic Process Regulation Of Cellular Process Viral Process Cellular Response To Stress Cell Cycle Regulation Of Cell Death Chromatin Organization Cell Cycle Process Negative Regulation Of Cell Cycle Activation Of MAPK Activity Response To Ionizing Radiation Chromatin Modification Apoptotic Signaling Pathway Regulation Of Organelle Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Establishment Of Golgi Localization Negative Regulation Of Centriole Replication Positive Regulation Of Cellular Protein Metabolic Process Adherens Junction Organization
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?