PRMT6 and GRHL3

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	GRHL3
Description		protein arginine methyltransferase 6	grainyhead like transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Chromatin Nucleus Nucleoplasm Cytosol Cilium Actin Cytoskeleton
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Establishment Of Planar Polarity Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Gene Expression Positive Regulation Of Gene Expression Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Eyelid Development In Camera-type Eye Establishment Of Skin Barrier Cochlea Morphogenesis
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Cleft palate ( 27018472) Fasting blood insulin (BMI interaction) ( 22581228) Male-pattern baldness ( 28196072) Response to interferon beta in multiple sclerosis ( 26644207)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	8 interacting genes: EAF1 ENKD1 GRHL1 GRHL2 PRMT1 PRMT5 PRMT6 RIPPLY1
Entrez ID		55170	57822
HPRD ID		10505	12210
Ensembl ID		ENSG00000198890	ENSG00000158055
Uniprot IDs		Q96LA8	Q8TE85
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylosome Regulation Of DNA-templated Transcription Methyltransferase Activity Regulation Of RNA Biosynthetic Process Histone H3 Methyltransferase Activity Methyl-CpG Binding Regulation Of RNA Metabolic Process Methylation Protein Methylation Regulation Of Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process GATOR1 Complex Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Epithelium Migration Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Peptidyl-arginine N-methylation Histone H3R2 Methyltransferase Activity Macromolecule Methylation Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Epithelial Cell Morphogenesis Involved In Placental Branching Intronic Transcription Regulatory Region Sequence-specific DNA Binding N-methyltransferase Activity Regulation Of Macromolecule Metabolic Process Epidermis Development Anterior Neural Tube Closure Positive Regulation Of Hemoglobin Biosynthetic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Somite Specification Regulation Of Multicellular Organismal Development Nucleoplasm Chromatin Remodeling Cellular Response To Methionine Super Elongation Complex Cell-cell Junction Organization Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4 Methyltransferase Activity
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