PRMT6 and RASSF2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	RASSF2
Gene Name		protein arginine methyltransferase 6	Ras association (RalGDS/AF-6) domain family member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Protein Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Skeletal System Development Ossification Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Via I-kappaB Kinase/NF-kappaB Cascade Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Bone Remodeling Homeostasis Of Number Of Cells Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	8 interactors: HRAS KDM1A KRAS PRMT3 PRMT6 RASSF5 STK3 SUV39H1
Entrez ID		55170	9770
HPRD ID		10505	15218
Ensembl ID		ENSG00000198890	ENSG00000101265
Uniprot IDs		Q96LA8	P50749
PDB IDs		4HC4
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Positive Regulation Of Rac Protein Signal Transduction Histone Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Methylation Regulation Of Cellular Protein Metabolic Process Peptidyl-arginine N-methylation Regulation Of Protein Metabolic Process Histone Arginine Methylation Protein Methylation Peptidyl-arginine Methylation Chromatin Modification Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Social Behavior Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of Metabolic Process Regulation Of Gene Expression Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Positive Regulation Of Protein Modification Process Muscle Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Response To Stress Chromosome Organization Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Epithelial Tube Morphogenesis Methylation Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Tube Morphogenesis Positive Regulation Of MAPK Cascade Associative Learning Regulation Of Primitive Erythrocyte Differentiation
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rhamm sult2a1 tff top2a
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rhamm sult2a1 tff top2a
Tagcloud (Intersection) ?