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PRMT6 and PSMD11
Number of citations of the paper that reports this interaction (PMID
23455924
)
3
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
PRMT6
PSMD11
Gene Name
protein arginine methyltransferase 6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Histone Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Histone Methyltransferase Activity (H3-R2 Specific)
Histone Methyltransferase Activity (H2A-R3 Specific)
Protein Binding
Biological Process
Base-excision Repair
Chromatin Organization
Transcription, DNA-templated
Viral Process
Histone Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Histone H3-R2 Methylation
Histone H4-R3 Methylation
Negative Regulation Of Transcription, DNA-templated
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome Assembly
Small Molecule Metabolic Process
Stem Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Intelligence (
22449649
)
Non-obstructive azoospermia (
22197933
)
Obesity (early onset extreme) (
23563609
)
Sex hormone-binding globulin levels (
22829776
)
Protein-Protein Interactions
91 interactors:
AK8
AP1G2
ASB3
AUNIP
BCAT1
BLZF1
BMP3
C17orf82
C8orf74
CDCA4
CETN2
DCAF16
DNAJA3
DNALI1
DXO
FBL
FIP1L1
FKBP7
FYCO1
FYN
GBE1
GRHL3
GSTCD
GTPBP2
H3F3C
HESX1
HIST1H4F
HIST2H2AA3
HIST2H2BE
HIST2H3A
HIST2H3C
HIST4H4
HMGA1
HMGA2
HNRNPH2
HOXA1
HOXA5
HOXC4
ID2
KIAA0408
KIF9
KLHL20
LDHAL6B
LENG8
LOXL4
MALT1
MED28
MLC1
MNDA
MRPL38
MTF2
NEFL
NOSTRIN
NR1D2
OAS1
OPA3
PABPC1
PCGF5
PELO
PEX7
PIAS1
PSMD11
PYCRL
PYGO1
RAC1
RAD17
RASSF2
SERGEF
SLU7
SMAD9
SMARCD1
SNF8
SPATA22
SPIN1
SPSB1
SRGAP3
SSX2IP
STARD10
SUV39H1
TDO2
TEX35
THEMIS
TMED5
TRIB2
TSC1
UBXN10
WBSCR27
WDFY3
ZNF436
ZNF557
ZSCAN9
33 interactors:
APP
BRD7
CCDC90B
CCSER2
COPS6
CRMP1
EEF1A1
EEF1G
GAPDH
GDF9
HAP1
IGSF21
LRIF1
MED31
NFKB2
PRKAA1
PRMT6
PTN
PTPRK
RBM48
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
TLE1
TP53
TUBB2A
UNC119
USP4
ZBTB16
ZHX1
Entrez ID
55170
5717
HPRD ID
10505
05119
Ensembl ID
ENSG00000198890
ENSG00000108671
Uniprot IDs
Q96LA8
O00231
PDB IDs
4HC4
Enriched GO Terms of Interacting Partners
?
Chromatin Silencing At RDNA
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Methylation On Cytosine
Chromatin Silencing
Gene Expression
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Expression, Epigenetic
Gene Silencing
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Cell Cycle
Cellular Metabolic Process
Organelle Organization
Oncogene-induced Cell Senescence
Chromatin Assembly Or Disassembly
Negative Regulation Of Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Cellular Process
Senescence-associated Heterochromatin Focus Assembly
DNA Methylation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Senescence
Histone H4-K20 Demethylation
Transcription, DNA-templated
Cochlea Morphogenesis
Chromatin Assembly
Embryonic Organ Morphogenesis
Cellular Macromolecule Biosynthetic Process
Cell Aging
RNA Biosynthetic Process
Nucleosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Senescence
Chromatin Organization
Macromolecule Biosynthetic Process
Chromosome Organization
Negative Regulation Of Megakaryocyte Differentiation
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription, DNA-templated
Cellular Response To Transforming Growth Factor Beta Stimulus
RNA Biosynthetic Process
RNA Metabolic Process
Response To Transforming Growth Factor Beta
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
SMAD Protein Complex Assembly
Negative Regulation Of Gene Expression
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryonic Pattern Specification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Response To Growth Factor
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mesonephros Development
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Primary MiRNA Processing
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Growth
Positive Regulation Of Gene Expression
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Developmental Growth
Tagcloud
?
bbrd
brucei
clade
clades
connects
dart
dihydrolipoamide
exemplified
fmr
homologues
methyltransferases
outgroup
paralogue
phylogeny
prmt1
prmt2
prmt3
prmt4
prmt5
prmt7
prmt8
prmt9
prmts
reconstructing
resolve
tbprmts
tedious
trypanosoma
uncharacterized
Tagcloud (Difference)
?
bbrd
brucei
clade
clades
connects
dart
dihydrolipoamide
exemplified
fmr
homologues
methyltransferases
outgroup
paralogue
phylogeny
prmt1
prmt2
prmt3
prmt4
prmt5
prmt7
prmt8
prmt9
prmts
reconstructing
resolve
tbprmts
tedious
trypanosoma
uncharacterized
Tagcloud (Intersection)
?