PRMT6 and DNALI1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	DNALI1
Gene Name		protein arginine methyltransferase 6	dynein, axonemal, light intermediate chain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Axonemal Dynein Complex Axoneme Filopodium
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Microtubule Motor Activity Protein Binding Dynein Heavy Chain Binding
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Movement Of Cell Or Subcellular Component Single Fertilization Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	6 interactors: ABCF3 APP EPS8 HTT PRMT6 SIAH1
Entrez ID		55170	7802
HPRD ID		10505	03681
Ensembl ID		ENSG00000198890	ENSG00000163879
Uniprot IDs		Q96LA8	B4DHN6 O14645
PDB IDs		4HC4
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Neuron Apoptotic Process Neuron Death Locomotory Behavior Axon Cargo Transport Mating Visual Learning Visual Behavior Single-organism Behavior Associative Learning Movement Of Cell Or Subcellular Component Neural Plate Formation Behavior Adult Locomotory Behavior Regulation Of Receptor Activity Response To External Stimulus Microtubule-based Transport Histone H3-R2 Methylation Synaptic Growth At Neuromuscular Junction Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Learning Cytoskeleton-dependent Intracellular Transport Transition Metal Ion Homeostasis Sexual Reproduction Adult Behavior Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Actin Polymerization-dependent Cell Motility Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Regulation Of Protein Phosphatase Type 2A Activity Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Neuron Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Lactate Biosynthetic Process Neuron Development Apoptotic Process Programmed Cell Death Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Paraxial Mesoderm Formation Reproduction Cell Death Death Exit From Mitosis Axon Choice Point Recognition Quinolinate Metabolic Process Cellular Response To CGMP Response To Stimulus
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	affymetrix anxa2 axonemal call carefully cytoskeleton discoveries dissected dynein endosomal exploration frontotemporal ftld inclusions insoluble landmark lobar mnd mortem myd88 networks neurodegenerative pgrn progranulin qrt sorting synapse u ubiquitinated
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	affymetrix anxa2 axonemal call carefully cytoskeleton discoveries dissected dynein endosomal exploration frontotemporal ftld inclusions insoluble landmark lobar mnd mortem myd88 networks neurodegenerative pgrn progranulin qrt sorting synapse u ubiquitinated
Tagcloud (Intersection) ?