PRMT6 and MNDA

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	MNDA
Description		protein arginine methyltransferase 6	myeloid cell nuclear differentiation antigen
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Azurophil Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	DNA Binding Double-stranded DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Activation Of Innate Immune Response Cellular Defense Response DNA Damage Response Negative Regulation Of B Cell Proliferation Cellular Response To Interferon-beta Positive Regulation Of Apoptotic Process B Cell Receptor Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Perceived intensity of aspartame ( 31005972)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	14 interacting genes: CDK1 CDK2 CEBPA CRK FBXO7 HOXB2 MAPK8IP2 NSD3 PRMT6 PRMT7 RB1 RBL2 STAT3 TP53
Entrez ID		55170	4332
HPRD ID		10505	15932
Ensembl ID		ENSG00000198890	ENSG00000163563
Uniprot IDs		Q96LA8	P41218 Q5VUU6
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	2DBG 5H7Q 5WPZ 8I6K
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Negative Regulation Of Cell Cycle Process Chromatin Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Intracellular Signaling Cassette Histone Methyltransferase Activity Regulation Of Lipid Kinase Activity Nucleoplasm Regulation Of Transcription By RNA Polymerase II Rb-E2F Complex Glial Cell Apoptotic Process Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Histone Kinase Activity Chromatin Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Processing Regulation Of Cell Cycle Process Cellular Senescence DNA-templated Transcription Cellular Response To Xenobiotic Stimulus Regulation Of Hemopoiesis Protein-arginine N-methyltransferase Activity Mitotic DNA Damage Checkpoint Signaling Protein-containing Complex Mitotic DNA Integrity Checkpoint Signaling Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Ras Protein Signal Transduction Regulation Of Cell Development G1/S Transition Of Mitotic Cell Cycle
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