PRMT6 and PYGO1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	PYGO1
Description		protein arginine methyltransferase 6	pygopus family PHD finger 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Chromatin Organization Spermatid Development Spermatid Nucleus Differentiation Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1
Entrez ID		55170	26108
HPRD ID		10505	06064
Ensembl ID		ENSG00000198890	ENSG00000171016
Uniprot IDs		Q96LA8	Q9Y3Y4
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	2VP7 2VPB 2VPD 2VPE 2VPG
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Beta-catenin-TCF Complex Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Cell Communication Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Signaling Maintenance Of Cell Number Muscle Cell Differentiation Canonical Wnt Signaling Pathway Stem Cell Population Maintenance Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Regulation Of Timing Of Anagen Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Protein-containing Complex Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion
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