FBL and PRMT8

Number of citations: 0 (PubMedID 17925405)
Data Source: BioGRID (enzymatic study)

		FBL	PRMT8
Name		fibrillarin	protein arginine methyltransferase 8
Structure
GO Annotations	Cellular Component	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Peptidyl-arginine Methylation Methylation Protein Homooligomerization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	None
GWAS		No GWAS studies recorded	Cardiac Troponin-T levels ( 31014085 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Gut microbiota (bacterial taxa) ( 27723756 ) HDL cholesterol ( 19060911 )
Interacting Genes		21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	20 interacting genes: CARM1 CEP162 COIL DCAF8 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 TNPO2 UBL5 VHL ZNF451
Entrez ID		2091	56341
HPRD ID		00617	11029
Ensembl ID		ENSG00000105202	ENSG00000111218
Uniprot IDs		P22087	Q59GT2 Q9NR22
PDB IDs		2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED	4X41 5DST
GO Terms Enriched among Interactors		Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair	Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Neurotrophin TRKA Receptor Binding Methyltransferase Activity Cajal Body Nucleus Negative Regulation Of Inflammatory Response Methylation Negative Regulation Of Developmental Process Protein Methyltransferase Activity Phosphatidylinositol 3-kinase Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Macromolecule Methylation Negative Regulation Of Defense Response Protein Modification Process Nucleoplasm Chromatin Remodeling U6 SnRNA 2'-O-ribose Methyltransferase Activity Regulation Of Apoptotic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Singlet Oxygen Protein Methylation Histone H3R8 Methyltransferase Activity GATOR1 Complex Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Developmental Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of Inflammatory Response