FBL and PRMT3

Number of citations: 0 (PubMedID 16157300)
Data Source: BioGRID (enzymatic study)

		FBL	PRMT3
Name		fibrillarin	protein arginine methyltransferase 3
Structure
GO Annotations	Cellular Component	Fibrillar Center Granular Component Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding Methyltransferase Activity RRNA Methyltransferase Activity Transferase Activity ATPase Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Histone H2AQ104 Methyltransferase Activity	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Metal Ion Binding
	Biological Process	Box C/D Sno(s)RNA 3'-end Processing Osteoblast Differentiation Chromatin Remodeling RRNA Processing Sno(s)RNA Metabolic Process RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis SnoRNA Localization	Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of Protein Ubiquitination Methylation Positive Regulation Of Osteoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Retinoic Acid Biosynthetic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	RMTs methylate histone arginines Protein methylation
Drugs		None	S-adenosyl-L-homocysteine
GWAS		No GWAS studies recorded	Carotid intima media thickness (maximum) ( 31801372 ) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906 ) Pursuit maintenance gain ( 29064472 ) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762 )
Interacting Genes		21 interacting genes: DDX17 DDX5 ERG H2AC20 KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PRMT8 PSMB6 PTEN RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17 ZNF792	11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 STAT1 TMEM132D TSC22D2
Entrez ID		2091	10196
HPRD ID		00617	11934
Ensembl ID		ENSG00000105202	ENSG00000185238
Uniprot IDs		P22087	O60678 Q8WUV3
PDB IDs		2IPX 7MQ8 7MQ9 7MQA 7SE6 7SE7 7SE8 7SE9 7SEA 7SEB 7SEC 7SED	2FYT 3SMQ 4HSG 4QQN 4RYL 8G2F 8G2G 8SHB 8SHR 8SIO
GO Terms Enriched among Interactors		Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Histone Methyltransferase Activity Box C/D SnoRNP Assembly Nucleoplasm Nucleus Chromatin Remodeling RNA Splicing Chromatin Organization Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Nucleic Acid Metabolic Process MLL1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine Methylation R2TP Complex Helicase Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Histone H4 Methyltransferase Activity Telomerase RNA Localization To Cajal Body Regulation Of RNA Metabolic Process RNA Processing Methyltransferase Activity Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process TFIID-class Transcription Factor Complex Binding SMN Complex RPAP3/R2TP/prefoldin-like Complex Regulation Of Nucleobase-containing Compound Metabolic Process Methylation Gemini Of Cajal Bodies Swr1 Complex Positive Regulation Of DNA Recombination Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination ATPase Binding Ino80 Complex MRNA Processing Regulation Of DNA Repair Regulation Of DNA Strand Elongation Protein Stabilization SMN-Sm Protein Complex Regulation Of Gene Expression Dynein Axonemal Particle Positive Regulation Of Double-strand Break Repair	Ribonucleoprotein Complex