PRMT6 and PEX7

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT6	PEX7
Gene Name		protein arginine methyltransferase 6	peroxisomal biogenesis factor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)	Peroxisome Matrix Targeting Signal-2 Binding Enzyme Binding Protein Homodimerization Activity
	Biological Process	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated	Neuron Migration Endochondral Ossification Fatty Acid Beta-oxidation Peroxisome Organization Ether Lipid Biosynthetic Process Protein Import Into Peroxisome Matrix
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9	7 interactors: ACAT1 KDM1A PEX13 PEX14 PEX5 PHYH PRMT6
Entrez ID		55170	5191
HPRD ID		10505	03454
Ensembl ID		ENSG00000198890	ENSG00000112357
Uniprot IDs		Q96LA8	O00628 Q6FGN1
PDB IDs		4HC4
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation	Protein Import Into Peroxisome Matrix, Docking Protein To Membrane Docking Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Negative Regulation Of Protein Homotetramerization Lipid Modification Carboxylic Acid Catabolic Process Peroxisome Organization Protein Import Into Peroxisome Matrix, Translocation Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Negative Regulation Of Protein Homooligomerization Fatty Acid Alpha-oxidation Membrane Docking Negative Regulation Of Protein Oligomerization Cellular Lipid Catabolic Process Protein Import Regulation Of Protein Oligomerization Brain Development Lipid Catabolic Process Head Development Fatty Acid Metabolic Process Cellular Lipid Metabolic Process Central Nervous System Development Establishment Of Protein Localization To Organelle Carboxylic Acid Metabolic Process Negative Regulation Of Protein Binding Organic Acid Metabolic Process Protein Targeting Protein Oligomerization Forebrain Development Lipid Metabolic Process Cerebral Cortex Cell Migration Peroxisome Transport Along Microtubule Cholesterol Storage Protein Import Into Peroxisome Matrix, Substrate Release Regulation Of Primitive Erythrocyte Differentiation Protein Localization To Organelle Telencephalon Cell Migration Forebrain Cell Migration Negative Regulation Of Binding Monocarboxylic Acid Metabolic Process Oxidation-reduction Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-R2 Methylation Microtubule-based Peroxisome Localization
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex6 pex8 pox1 puf5 rbp rfp
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex6 pex8 pox1 puf5 rbp rfp
Tagcloud (Intersection) ?