DRD2 and SPP1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		DRD2	SPP1
Description		dopamine receptor D2	secreted phosphoprotein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Plasma Membrane Cilium Membrane Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Presynaptic Membrane Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Heterotrimeric G-protein Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding
	Biological Process	Temperature Homeostasis Response To Hypoxia Neuron Migration Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Intracellular Calcium Ion Homeostasis Autophagy Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Neuroblast Proliferation Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Visual Learning Response To Xenobiotic Stimulus Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Cell Migration Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Adult Behavior Forebrain Development Auditory Behavior Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Negative Regulation Of Dephosphorylation Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonate Secretion Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Ethanol Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Secretion By Cell Hyaloid Vascular Plexus Regression Negative Regulation Of Neuron Migration	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion
Pathways		Dopamine receptors	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 33861876) Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 29255261 27089181) Problematic alcohol use ( 32451486) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 30285260 29483656 28991256 25056061) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Sociability score ( 34054130) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531) Walking pace ( 33128006) Worry too long after an embarrassing experience ( 34054130)	Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)
Interacting Genes		86 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CCKBR CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPR137 GPR37 GRIA2 GRINA HRH3 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B RHBDD2 RTN1 RTN3 RTN4 SERINC3 SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 WFS1 WLS YIPF3 ZDHHC4	97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		1813	6696
HPRD ID		00539	01325
Ensembl ID		ENSG00000149295	ENSG00000118785
Uniprot IDs		P14416	B7Z351 P10451 Q3LGB0
PDB IDs		5AER 6CM4 6LUQ 6VMS 7DFP 7JVR 8IRS 8TZQ 8U02	3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Synapse Dendrite Inorganic Cation Transmembrane Transport Regulation Of Transport Presynaptic Membrane Metal Ion Transport G Protein-coupled Receptor Activity Endoplasmic Reticulum Membrane Golgi Membrane Dendritic Shaft Endoplasmic Reticulum Tubular Network Formation Amino Acid Transport Neuronal Cell Body Negative Regulation Of Voltage-gated Calcium Channel Activity Endoplasmic Reticulum Tubular Network Membrane Organization Calcium Channel Complex Neuropeptide Binding Regulation Of Signaling Negative Regulation Of Adenylate Cyclase Activity Dendritic Spine Negative Regulation Of High Voltage-gated Calcium Channel Activity G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Heterotrimeric G-protein Complex Secretion Regulation Of Cell Communication Golgi Apparatus Postsynaptic Membrane Positive Regulation Of Signaling Regulation Of Voltage-gated Calcium Channel Activity Membrane Organization Gamma-delta T Cell Receptor Complex GABA Receptor Complex Ligand-gated Monoatomic Cation Channel Activity Cellular Response To Morphine D2 Dopamine Receptor Binding Endoplasmic Reticulum Membrane Organization Regulation Of Secretion By Cell	Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion
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