DRD2 and RBM22

		DRD2	RBM22
Description		dopamine receptor D2	RNA binding motif protein 22
Image
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Plasma Membrane Cilium Membrane Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Presynaptic Membrane Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Heterotrimeric G-protein Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding U6 SnRNA Binding Pre-mRNA Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Temperature Homeostasis Response To Hypoxia Neuron Migration Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Intracellular Calcium Ion Homeostasis Autophagy Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Neuroblast Proliferation Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Visual Learning Response To Xenobiotic Stimulus Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Cell Migration Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Adult Behavior Forebrain Development Auditory Behavior Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Negative Regulation Of Dephosphorylation Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonate Secretion Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Ethanol Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Secretion By Cell Hyaloid Vascular Plexus Regression Negative Regulation Of Neuron Migration	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of RNA Splicing Positive Regulation Of Protein Import Into Nucleus MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Cellular Response To Xenobiotic Stimulus
Pathways		Dopamine receptors	mRNA Splicing - Major Pathway
Drugs		Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 33861876) Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 29255261 27089181) Problematic alcohol use ( 32451486) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 30285260 29483656 28991256 25056061) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Sociability score ( 34054130) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531) Walking pace ( 33128006) Worry too long after an embarrassing experience ( 34054130)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		86 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CCKBR CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPR137 GPR37 GRIA2 GRINA HRH3 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B RHBDD2 RTN1 RTN3 RTN4 SERINC3 SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 WFS1 WLS YIPF3 ZDHHC4	45 interacting genes: AQR BAG4 BCAS2 BICD2 BMI1 CEBPA CEP55 CTBP1 CYSRT1 DMRTB1 EIF4ENIF1 ESS2 EXOSC7 EXOSC8 GIGYF1 GOLGA2 HNRNPUL1 HOMER3 HOOK1 KRT31 NCKIPSD NOA1 NXF1 OGT PQBP1 PRC1 PRMT2 PRNP PRPF39 PRPF6 RBFOX2 RBM4 RBPMS RNU6-1 RNU6-50P RNU6-6P SNRPA SNW1 TFIP11 TXNL4A VIM WBP4 YBX2 YTHDF1 YTHDF3
Entrez ID		1813	55696
HPRD ID		00539	10186
Ensembl ID		ENSG00000149295	ENSG00000086589
Uniprot IDs		P14416	Q9NW64
PDB IDs		5AER 6CM4 6LUQ 6VMS 7DFP 7JVR 8IRS 8TZQ 8U02	2YTC 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Synapse Dendrite Inorganic Cation Transmembrane Transport Regulation Of Transport Presynaptic Membrane Metal Ion Transport G Protein-coupled Receptor Activity Endoplasmic Reticulum Membrane Golgi Membrane Dendritic Shaft Endoplasmic Reticulum Tubular Network Formation Amino Acid Transport Neuronal Cell Body Negative Regulation Of Voltage-gated Calcium Channel Activity Endoplasmic Reticulum Tubular Network Membrane Organization Calcium Channel Complex Neuropeptide Binding Regulation Of Signaling Negative Regulation Of Adenylate Cyclase Activity Dendritic Spine Negative Regulation Of High Voltage-gated Calcium Channel Activity G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Heterotrimeric G-protein Complex Secretion Regulation Of Cell Communication Golgi Apparatus Postsynaptic Membrane Positive Regulation Of Signaling Regulation Of Voltage-gated Calcium Channel Activity Membrane Organization Gamma-delta T Cell Receptor Complex GABA Receptor Complex Ligand-gated Monoatomic Cation Channel Activity Cellular Response To Morphine D2 Dopamine Receptor Binding Endoplasmic Reticulum Membrane Organization Regulation Of Secretion By Cell	RNA Splicing MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Spliceosomal Complex RNA Binding RNA Metabolic Process Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Membraneless Organelle Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleus Identical Protein Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm U2-type Catalytic Step 2 Spliceosome Cellular Component Assembly Exoribonuclease Complex Regulation Of RNA Splicing Nucleic Acid Binding P-body Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation U4 SnRNA 3'-end Processing Regulation Of Long-term Synaptic Potentiation Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Translational Initiation Memory RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome TRNA Decay Nuclear MRNA Surveillance Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Pre-mRNA Intronic Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?