DRD2 and ADORA2A

Number of citations of the paper that reports this interaction (PubMedID 12804599)
0

Data Source:
HPRD (in vivo)

		DRD2	ADORA2A
Description		dopamine receptor D2	adenosine A2a receptor
Image
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Plasma Membrane Cilium Membrane Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Presynaptic Membrane Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse	Intermediate Filament Plasma Membrane Membrane Axon Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Presynaptic Active Zone Glutamatergic Synapse
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Heterotrimeric G-protein Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Calmodulin Binding Lipid Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process	Temperature Homeostasis Response To Hypoxia Neuron Migration Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Intracellular Calcium Ion Homeostasis Autophagy Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Neuroblast Proliferation Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Visual Learning Response To Xenobiotic Stimulus Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Cell Migration Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Adult Behavior Forebrain Development Auditory Behavior Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Negative Regulation Of Dephosphorylation Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonate Secretion Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Ethanol Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Secretion By Cell Hyaloid Vascular Plexus Regression Negative Regulation Of Neuron Migration	Synaptic Transmission, Dopaminergic G Protein-coupled Adenosine Receptor Signaling Pathway Response To Amphetamine Regulation Of DNA-templated Transcription Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Purine-containing Compound Response To Caffeine Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Vasodilation Eating Behavior Negative Regulation Of Vascular Permeability Response To Alkaloid Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Alpha-beta T Cell Activation Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Dopamine receptors	NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism
Drugs		Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil	Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline KW-6356
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 33861876) Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 29255261 27089181) Problematic alcohol use ( 32451486) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 30285260 29483656 28991256 25056061) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Sociability score ( 34054130) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531) Walking pace ( 33128006) Worry too long after an embarrassing experience ( 34054130)	Acne (severe) ( 24927181) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		86 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CCKBR CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPR137 GPR37 GRIA2 GRINA HRH3 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B RHBDD2 RTN1 RTN3 RTN4 SERINC3 SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 WFS1 WLS YIPF3 ZDHHC4	25 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CHN1 CNR1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SNCA SPNS1 SYNGR1
Entrez ID		1813	135
HPRD ID		00539	00043
Ensembl ID		ENSG00000149295	ENSG00000128271
Uniprot IDs		P14416	A8K1F6 B3KVQ4 P29274 X5DNB4
PDB IDs		5AER 6CM4 6LUQ 6VMS 7DFP 7JVR 8IRS 8TZQ 8U02	2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 7ARO 7EZC 7PX4 7PYR 7RM5 7T32 8A2O 8A2P 8C9W 8CIC 8CU6 8CU7 8DU3 8GNE 8GNG 8JWY 8JWZ 8PWN 8RQQ 8RVW 8RW0 8RW4 8RW7 8RWC 8RWD 8RWE 8RWH 8RWI 8RWX 8UGW 8WDT 9FUP
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Synapse Dendrite Inorganic Cation Transmembrane Transport Regulation Of Transport Presynaptic Membrane Metal Ion Transport G Protein-coupled Receptor Activity Endoplasmic Reticulum Membrane Golgi Membrane Dendritic Shaft Endoplasmic Reticulum Tubular Network Formation Amino Acid Transport Neuronal Cell Body Negative Regulation Of Voltage-gated Calcium Channel Activity Endoplasmic Reticulum Tubular Network Membrane Organization Calcium Channel Complex Neuropeptide Binding Regulation Of Signaling Negative Regulation Of Adenylate Cyclase Activity Dendritic Spine Negative Regulation Of High Voltage-gated Calcium Channel Activity G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Heterotrimeric G-protein Complex Secretion Regulation Of Cell Communication Golgi Apparatus Postsynaptic Membrane Positive Regulation Of Signaling Regulation Of Voltage-gated Calcium Channel Activity Membrane Organization Gamma-delta T Cell Receptor Complex GABA Receptor Complex Ligand-gated Monoatomic Cation Channel Activity Cellular Response To Morphine D2 Dopamine Receptor Binding Endoplasmic Reticulum Membrane Organization Regulation Of Secretion By Cell	Pseudopodium Cortical Actin Cytoskeleton Cell Junction Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Synapse Actin Cytoskeleton Plasma Membrane Focal Adhesion Assembly Positive Regulation Of MAPK Cascade Phenol-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of ERK1 And ERK2 Cascade Dopamine Metabolic Process Muscle Cell Development Response To Iron Ion Leukotriene C4 Gamma-glutamyl Transferase Activity Cell-substrate Junction Assembly Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Cell-substrate Junction Organization Presynapse Catecholamine Metabolic Process Glutathione Hydrolase Activity Leukotriene D4 Biosynthetic Process Fascia Adherens Negative Regulation Of Oxidative Phosphorylation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Calcium Ion Binding Transmembrane Transporter Binding Focal Adhesion Z Disc Cell Junction Assembly Negative Regulation Of Cellular Respiration Glutathione Catabolic Process Dopamine Biosynthetic Process Postsynaptic Actin Cytoskeleton Regulation Of Intracellular Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Glutathione Metabolic Process Positive Regulation Of Intracellular Signal Transduction Integrin Binding Sarcomere Cell Junction Organization Response To Inactivity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Neuronal Synaptic Plasticity Catecholamine Uptake
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