DRD2 and PAWR

Number of citations of the paper that reports this interaction (PMID 16051151)
24

Data Source:
BioGRID (pull down, two hybrid)

		DRD2	PAWR
Gene Name		dopamine receptor D2	PRKC, apoptosis, WT1, regulator
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Dendritic Spine Perikaryon Axon Terminus	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Potassium Channel Regulator Activity Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Temperature Homeostasis Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G-protein Coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Protein Localization Negative Regulation Of Cell Proliferation Associative Learning Visual Learning Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Response To Inactivity Wnt Signaling Pathway Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Regulation Of CAMP Metabolic Process Auditory Behavior Activation Of Protein Kinase Activity Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Response To Drug Regulation Of Potassium Ion Transport Response To Morphine Pigmentation Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Voltage-gated Calcium Channel Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Chlorpromazine Buspirone Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupenthixol Amantadine Mesoridazine Dopamine Carphenazine Acetophenazine Promethazine Pimozide Doxepin Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Iloperidone Rotigotine Sertindole Asenapine Amisulpride Lurasidone
Diseases
GWAS		Select biomarker traits ( 17903293) Working memory ( 21107309)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		21 interactors: ADORA2A CADPS CADPS2 CALM1 CLIC6 EPB41 EPB41L1 FLNA GIPC1 GNAI2 GNAI3 GNAZ GRIA2 KCNJ6 KCNJ9 NCS1 NSF PAWR PPP1R9B SLC6A3 SSTR5	17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		1813	5074
HPRD ID		00539	09051
Ensembl ID		ENSG00000149295
Uniprot IDs		F8VUV1 P14416	Q96IZ0
PDB IDs		1I15	2JK9
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Secretion Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Secretion By Cell Transport Regulation Of Body Fluid Levels Exocytosis Regulation Of Ion Transport Regulation Of Cytokinesis Platelet Activation Regulation Of Ion Transmembrane Transport Blood Coagulation Synaptic Vesicle Priming Hemostasis Adenosine Receptor Signaling Pathway Regulation Of Cell Division Ion Transport Wound Healing Actin Cytoskeleton Organization Vesicle-mediated Transport Negative Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Localization Actin Filament-based Process Negative Regulation Of Lyase Activity Cortical Actin Cytoskeleton Organization Potassium Ion Import Monoamine Transport Regulation Of Neurotransmitter Levels Cortical Cytoskeleton Organization Activation Of Adenylate Cyclase Activity Response To Wounding Negative Regulation Of CAMP Biosynthetic Process Regulation Of Exocytosis Negative Regulation Of CAMP Metabolic Process Neurotransmitter Transport Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cytokinesis Negative Regulation Of Nucleotide Metabolic Process Metal Ion Transport	Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress
Tagcloud ?		a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?		a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?