SH3D19 and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3D19	SH3RF1
Description		SH3 domain containing 19	SH3 domain containing ring finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Proline-rich Region Binding	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis	RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1
Entrez ID		152503	57630
HPRD ID		16364	15335
Ensembl ID		ENSG00000109686	ENSG00000154447
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	Q7Z6J0
PDB IDs			7NZC 7NZD
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm
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