SH3D19 and ADAM12

Number of citations of the paper that reports this interaction (PMID 15280379)
19

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SH3D19	ADAM12
Gene Name		SH3 domain containing 19	ADAM metallopeptidase domain 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Extracellular Region Nucleoplasm Mitochondrion Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Post-Golgi Vesicle-mediated Transport Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Membrane Organization	Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Myoblast Fusion
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Signaling by EGFR Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Protein-Protein Interactions		11 interactors: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3YL1 SOS2	11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1
Entrez ID		152503	8038
HPRD ID		16364	04092
Ensembl ID		ENSG00000109686	ENSG00000148848
Uniprot IDs		Q5HYK7	A8K6G4 O43184
PDB IDs
Enriched GO Terms of Interacting Partners?		PMA-inducible Membrane Protein Ectodomain Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Collagen Metabolic Process Membrane Protein Ectodomain Proteolysis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Protein Proteolysis Anatomical Structure Development Signal Transduction Developmental Process Monocyte Activation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Signaling Regulation Of Cellular Component Organization Cell Communication System Development Regulation Of ERBB Signaling Pathway Positive Regulation Of T Cell Chemotaxis Cell Morphogenesis Involved In Differentiation Cell Surface Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell Differentiation Axon Guidance Integrin-mediated Signaling Pathway Cellular Response To Stimulus Anatomical Structure Morphogenesis Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Notch Receptor Processing Cell Morphogenesis Response To External Stimulus Axonogenesis Regulation Of Lymphocyte Migration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Wound Healing Chemotaxis	Blood Coagulation Hemostasis Platelet Activation Vesicle-mediated Transport T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Regulation Of Cellular Component Organization Response To Wounding Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Carbohydrate Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Smooth Muscle Cell Migration Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organonitrogen Compound Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Leukocyte Migration Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Phagocytosis Regulation Of Cell Adhesion Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Activation Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Regulation Of Immune System Process Cellular Response To Peptide
Tagcloud ?			alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Difference) ?			alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Intersection) ?