SH3D19 and ADAM10

Number of citations of the paper that reports this interaction (PMID 15280379)
19

Data Source:
HPRD (in vivo)

		SH3D19	ADAM10
Gene Name		SH3 domain containing 19	ADAM metallopeptidase domain 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Nucleus Cytoplasm Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Focal Adhesion Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding Proline-rich Region Binding	Endopeptidase Activity Metalloendopeptidase Activity Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Post-Golgi Vesicle-mediated Transport Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Membrane Organization	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Tumor Necrosis Factor Monocyte Activation Ephrin Receptor Signaling Pathway PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Collagen degradation Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by EGFR Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3YL1 SOS2	7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		152503	102
HPRD ID		16364	03723
Ensembl ID		ENSG00000109686	ENSG00000137845
Uniprot IDs		Q5HYK7	B4DU28 O14672
PDB IDs			1M1I
Enriched GO Terms of Interacting Partners?		PMA-inducible Membrane Protein Ectodomain Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Collagen Metabolic Process Membrane Protein Ectodomain Proteolysis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Protein Proteolysis Anatomical Structure Development Signal Transduction Developmental Process Monocyte Activation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Signaling Regulation Of Cellular Component Organization Cell Communication System Development Regulation Of ERBB Signaling Pathway Positive Regulation Of T Cell Chemotaxis Cell Morphogenesis Involved In Differentiation Cell Surface Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell Differentiation Axon Guidance Integrin-mediated Signaling Pathway Cellular Response To Stimulus Anatomical Structure Morphogenesis Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Notch Receptor Processing Cell Morphogenesis Response To External Stimulus Axonogenesis Regulation Of Lymphocyte Migration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Wound Healing Chemotaxis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Cell Surface Receptor Signaling Pathway Cell Development Substrate Adhesion-dependent Cell Spreading Regulation Of Epithelial To Mesenchymal Transition Cell Morphogenesis Axon Guidance Nervous System Development System Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Axonogenesis Regulation Of Signal Transduction Multicellular Organismal Development Regulation Of Neuron Differentiation Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Tissue Remodeling Chemotaxis Organ Development Regulation Of Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Auditory Receptor Cell Differentiation Hemopoiesis Regulation Of Signaling Neuron Projection Morphogenesis Signal Transduction Activation Of MAPK Activity Immune System Development Regulation Of Neurogenesis Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Differentiation Response To External Stimulus Signaling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Communication
Tagcloud ?			actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle
Tagcloud (Difference) ?			actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle
Tagcloud (Intersection) ?