SH3D19 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SH3D19	SYNJ1
Description		SH3 domain containing 19	synaptojanin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	Protein Binding Proline-rich Region Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		Golgi Associated Vesicle Biogenesis	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	30 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2
Entrez ID		152503	8867
HPRD ID		16364	09182
Ensembl ID		ENSG00000109686	ENSG00000159082
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery
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