SH3D19 and ADAM15

Number of citations of the paper that reports this interaction (PMID 15280379)
19

Data Source:
HPRD (in vivo)

		SH3D19	ADAM15
Gene Name		SH3 domain containing 19	ADAM metallopeptidase domain 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Proline-rich Region Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Post-Golgi Vesicle-mediated Transport Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Membrane Organization	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		11 interactors: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3YL1 SOS2	32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		152503	8751
HPRD ID		16364	05674
Ensembl ID		ENSG00000109686	ENSG00000143537
Uniprot IDs		Q5HYK7	B4DMH8 Q13444 U3KQL5
PDB IDs
Enriched GO Terms of Interacting Partners?		PMA-inducible Membrane Protein Ectodomain Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Collagen Metabolic Process Membrane Protein Ectodomain Proteolysis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Protein Proteolysis Anatomical Structure Development Signal Transduction Developmental Process Monocyte Activation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Signaling Regulation Of Cellular Component Organization Cell Communication System Development Regulation Of ERBB Signaling Pathway Positive Regulation Of T Cell Chemotaxis Cell Morphogenesis Involved In Differentiation Cell Surface Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell Differentiation Axon Guidance Integrin-mediated Signaling Pathway Cellular Response To Stimulus Anatomical Structure Morphogenesis Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Notch Receptor Processing Cell Morphogenesis Response To External Stimulus Axonogenesis Regulation Of Lymphocyte Migration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Wound Healing Chemotaxis	Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?			adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?