CSF3R and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 12133942)
0

Data Source:
HPRD (in vivo)

		CSF3R	SOCS3
Description		colony stimulating factor 3 receptor	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Cytosol Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim
Diseases
GWAS		Basophil count ( 32888494) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 29403010 32888494)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		1441	9021
HPRD ID		00737	05006
Ensembl ID		ENSG00000119535	ENSG00000184557
Uniprot IDs		Q99062	O14543 Q6FI39
PDB IDs		2D9Q
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?