CSF3R and WSB1

Number of citations of the paper that reports this interaction (PubMedID 17001306)
0

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		CSF3R	WSB1
Description		colony stimulating factor 3 receptor	WD repeat and SOCS box containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Cytoplasm Cytosol
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Protein Polyubiquitination Protein Ubiquitination Intracellular Signal Transduction Protein K27-linked Ubiquitination Protein Aggregate Center Assembly
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim
Diseases
GWAS		Basophil count ( 32888494) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 29403010 32888494)	Birth weight ( 31043758) Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	8 interacting genes: AXIN1 CSF3R DIO2 HIPK2 LRRK2 UBE2D2 UBE2D3 VHL
Entrez ID		1441	26118
HPRD ID		00737	15680
Ensembl ID		ENSG00000119535	ENSG00000109046
Uniprot IDs		Q99062	Q8NC76 Q9Y6I7
PDB IDs		2D9Q
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Wnt Signalosome Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Protein Polyubiquitination Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Cell Communication Negative Regulation Of Signaling SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Post-translational Protein Modification Granulocyte Colony-stimulating Factor Binding Protein Autoubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of BMP Signaling Pathway Beta-catenin Destruction Complex Assembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Macromolecule Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of Transcription Elongation By RNA Polymerase II Canonical Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Axial Mesoderm Formation Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
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