CSF3R and WSB1

Number of citations of the paper that reports this interaction (PMID 17001306)
3

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		CSF3R	WSB1
Gene Name		colony stimulating factor 3 receptor (granulocyte)	WD repeat and SOCS box containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Intracellular
	Molecular Function	Receptor Activity Cytokine Receptor Activity Protein Binding	Protein Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis	Biological_process Protein Ubiquitination Intracellular Signal Transduction
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Pegfilgrastim Filgrastim
Diseases
GWAS			Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)
Protein-Protein Interactions		19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	5 interactors: CSF3R DIO2 GSK3B HIPK2 UBE2D3
Entrez ID		1441	26118
HPRD ID		00737	15680
Ensembl ID		ENSG00000119535	ENSG00000109046
Uniprot IDs		Q99062	B4DGB8 Q9Y6I7
PDB IDs		1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus	Positive Regulation Of Protein Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Response To Oxygen Levels Peptidyl-serine Phosphorylation Positive Regulation Of Binding Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Thyroid Hormone Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Response To Transforming Growth Factor Beta Apoptotic Process Organ Morphogenesis Programmed Cell Death Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Voluntary Musculoskeletal Movement Cell Death Death Response To Abiotic Stimulus PML Body Organization Cellular Response To Interleukin-3 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Selenocysteine Incorporation Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Surface Receptor Signaling Pathway Response To Hypoxia Hormone Catabolic Process Protein Localization To Microtubule Defense Response Negative Regulation Of Biosynthetic Process Iris Morphogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Response To Stress Apoptotic Signaling Pathway Lens Induction In Camera-type Eye ER Overload Response
Tagcloud ?		1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f	293t carrier chimera chimeric d2 deiodinase deiodinases deiodination direction e3 extensively globular govern hek insertion instability introducing k237 k244 ligase lysines march6 readily teb4 thyroxine transiently ubiquitinate ubiquitination unless
Tagcloud (Difference) ?		1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f	293t carrier chimera chimeric d2 deiodinase deiodinases deiodination direction e3 extensively globular govern hek insertion instability introducing k237 k244 ligase lysines march6 readily teb4 thyroxine transiently ubiquitinate ubiquitination unless
Tagcloud (Intersection) ?