CSF3R and FTH1

Number of citations of the paper that reports this interaction (PMID 15123426)
5

Data Source:
HPRD (in vitro)

		CSF3R	FTH1
Gene Name		colony stimulating factor 3 receptor (granulocyte)	ferritin, heavy polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Nucleus Mitochondrion Cytosol Intracellular Ferritin Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Cytokine Receptor Activity Protein Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Immune Response Negative Regulation Of Cell Proliferation Negative Regulation Of Fibroblast Proliferation Transmembrane Transport Oxidation-reduction Process Membrane Organization
Pathways			Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Pegfilgrastim Filgrastim	Iron Dextran
Diseases
GWAS			Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	31 interactors: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 PACSIN1 PIAS4 SDCBP SOX5 SPP1 TICAM2 TOLLIP TRAF4 UBR1 WDYHV1 YWHAE
Entrez ID		1441	2495
HPRD ID		00737	00615
Ensembl ID		ENSG00000119535	ENSG00000167996
Uniprot IDs		Q99062	P02794
PDB IDs		1AZ7 2D9Q	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus	Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Metabolic Process Chemotaxis Positive Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Response To Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Communication Regulation Of Protein Metabolic Process System Development Movement Of Cell Or Subcellular Component Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Generation Of Neurons Anatomical Structure Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Toll-like Receptor Signaling Pathway Locomotion Positive Regulation Of Protein Sumoylation Signaling Response To Hormone Neurogenesis Cellular Response To Lipid Leukocyte Migration Signal Transduction Regulation Of Signaling Steroid Hormone Mediated Signaling Pathway Multicellular Organismal Development Regulation Of Protein Sumoylation Response To External Stimulus Leukocyte Chemotaxis Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of JNK Cascade Cell Migration Response To Lipid Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Transcription From RNA Polymerase II Promoter Cell Motility Negative Regulation Of Gene Expression
Tagcloud ?		1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?