CSF3R and WSB2

Number of citations of the paper that reports this interaction (PubMedID 17001306)
0

Data Source:
BioGRID (affinity chromatography technology, imaging technique, protein complementation assay)

		CSF3R	WSB2
Description		colony stimulating factor 3 receptor	WD repeat and SOCS box containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Cytosol
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Protein Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Protein Polyubiquitination Protein Ubiquitination Intracellular Signal Transduction
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Neddylation
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim
Diseases
GWAS		Basophil count ( 32888494) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 29403010 32888494)	Chronic rhinosinusitis ( 33393196) Red blood cell count ( 32888494)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	3 interacting genes: CSF3R EZH2 RPN1
Entrez ID		1441	55884
HPRD ID		00737	18305
Ensembl ID		ENSG00000119535	ENSG00000176871
Uniprot IDs		Q99062	Q9NYS7
PDB IDs		2D9Q
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Granulocyte Colony-stimulating Factor Binding Hepatocyte Homeostasis Cellular Response To Trichostatin A Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Amelogenesis Regulation Of Retinoic Acid Receptor Signaling Pathway Cellular Response To Antibiotic Cardiac Muscle Hypertrophy In Response To Stress ESC/E(Z) Complex Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Phosphorylation Primary MiRNA Binding Histone H3K27 Methyltransferase Activity G1 To G0 Transition Subtelomeric Heterochromatin Formation Facultative Heterochromatin Formation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Dendrite Development Cerebellar Cortex Development Chromatin Silencing Complex Oligosaccharyltransferase Complex B Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Oligosaccharyltransferase Complex Oligosaccharyltransferase Complex A Negative Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA-templated DNA Replication
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