CSF3R and CSF3

Number of citations of the paper that reports this interaction (PubMedID 10364174)
0

Data Source:
HPRD (in vivo)

		CSF3R	CSF3
Description		colony stimulating factor 3 receptor	colony stimulating factor 3
Image
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Extracellular Region Extracellular Space Lysosomal Lumen Endocytic Vesicle Lumen
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Signaling Receptor Binding Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Other interleukin signaling Interleukin-10 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim
Diseases
GWAS		Basophil count ( 32888494) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 29403010 32888494)	Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 20172861 32888494 27863252 25096241) Neutrophil percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 24390342 30423114) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 20139978 32888494 29403010 28158719 27863252 21738480) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	6 interacting genes: CSF3R ELANE PARVG S100A6 S100P TBX3
Entrez ID		1441	1440
HPRD ID		00737	00736
Ensembl ID		ENSG00000119535	ENSG00000108342
Uniprot IDs		Q99062	P09919 Q6FH65 Q8N4W3
PDB IDs		2D9Q	1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle G1/S Phase Transition Y Chromosome Positive Regulation Of Heterochromatin Formation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cellular Senescence Granulocyte Colony-stimulating Factor Binding Cytokine Binding Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Chemotaxis Neutrophil-mediated Killing Of Fungus Positive Regulation Of Interleukin-8 Production Protein Homodimerization Activity Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Calcium-dependent Protein Binding Follicle-stimulating Hormone Secretion Atrioventricular Bundle Cell Differentiation Limbic System Development Ureteric Peristalsis Hepatoblast Differentiation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Regulation Of Interleukin-8 Production Antibacterial Peptide Biosynthetic Process NAD(P)H Dehydrogenase (quinone) Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Mammary Placode Formation His-Purkinje System Cell Differentiation Specification Of Animal Organ Position
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