CSF3R and PLA2G1B

Number of citations of the paper that reports this interaction (PubMedID 14557262)
0

Data Source:
HPRD (in vitro)

		CSF3R	PLA2G1B
Description		colony stimulating factor 3 receptor	phospholipase A2 group IB
Image
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Phospholipid Binding Hydrolase Activity Bile Acid Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Innate Immune Response In Mucosa Neutrophil Mediated Immunity Lipid Metabolic Process Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of D-glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonate Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Podocyte Apoptotic Process
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Developmental Lineage of Pancreatic Acinar Cells
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim	Fluocinolone acetonide Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
Diseases
GWAS		Basophil count ( 32888494) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 29403010 32888494)	Bipolar disorder ( 31043756)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		1441	5319
HPRD ID		00737	01396
Ensembl ID		ENSG00000119535	ENSG00000170890
Uniprot IDs		Q99062	P04054
PDB IDs		2D9Q	3ELO 6Q42
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Articular Cartilage Development Defense Response Regulation Of Developmental Process Granulocyte Colony-stimulating Factor Binding Amelogenesis Regulation Of Neutrophil Activation Intestinal Stem Cell Homeostasis Calcium-dependent Phospholipase A2 Activity Phospholipid Metabolic Process Positive Regulation Of Developmental Process Growth Hormone Receptor Binding Regulation Of Developmental Growth Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Erythropoietin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Growth Hormone Receptor Signaling Pathway JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Positive Regulation Of Neuron Migration Positive Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Ubiquitin Recycling Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Protein Polyubiquitination Phospholipase A2 Activator Activity Regulation Of Protein K63-linked Ubiquitination Low-density Lipoprotein Particle Remodeling Insulin-like Growth Factor Receptor Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mammary Gland Alveolus Development Regulation Of Cell Growth Cytokine-mediated Signaling Pathway Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Dendrite Extension Arachidonate Secretion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?