CNP and MTNR1A

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vivo)

		CNP	MTNR1A
Gene Name		2,3-cyclic nucleotide 3 phosphodiesterase	melatonin receptor 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Microtubule Plasma Membrane Microvillus Membrane Pseudopodium Myelin Sheath Abaxonal Region Myelin Sheath Adaxonal Region Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	RNA Binding 2',3'-cyclic-nucleotide 3'-phosphodiesterase Activity Cyclic Nucleotide Binding	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process	Microtubule Cytoskeleton Organization Synaptic Transmission Axonogenesis Aging Adult Locomotory Behavior Cyclic Nucleotide Catabolic Process Response To Toxic Substance Substantia Nigra Development Forebrain Development Response To Lipopolysaccharide Regulation Of Mitochondrial Membrane Permeability Oligodendrocyte Differentiation	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		5 interactors: MTNR1A PPP1CA PRKCD PRNP TUBA1A	26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB
Entrez ID		1267	4543
HPRD ID		00448	02812
Ensembl ID		ENSG00000173786	ENSG00000168412
Uniprot IDs		P09543	P48039
PDB IDs		1WOJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipid Catabolic Process Circadian Rhythm Interleukin-10 Production Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Filopodium Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Signal Transduction Interleukin-12 Production Negative Regulation Of Signaling Positive Regulation Of Ceramide Biosynthetic Process Cellular Response To Copper Ion Negative Regulation Of Calcium-mediated Signaling Regulation Of Ceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipid Transport Cellular Response To Stimulus Negative Regulation Of Platelet Aggregation Negative Regulation Of Interleukin-17 Production Positive Regulation Of Superoxide Anion Generation Regulation Of Glycogen Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell-cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of Cell Death Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Regulation Of Superoxide Anion Generation Response To Oxidative Stress Cell Division Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Positive Regulation Of CGMP Biosynthetic Process Regulation Of Cell Activation Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Response To External Stimulus Positive Regulation Of CGMP Metabolic Process Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation	Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		b blot caused culture e1 exposure gamma increases influence mc3t3 metabolism microm might moderate mrnas natriuretic northern npr osteoblastic peptide promotes rar retinoic retinoid retinoids rxr system unchanged x
Tagcloud (Difference) ?		b blot caused culture e1 exposure gamma increases influence mc3t3 metabolism microm might moderate mrnas natriuretic northern npr osteoblastic peptide promotes rar retinoic retinoid retinoids rxr system unchanged x
Tagcloud (Intersection) ?