CNP and TUBA1A

Number of citations of the paper that reports this interaction (PMID 11842207)
19

Data Source:
HPRD (in vitro)

		CNP	TUBA1A
Gene Name		2,3-cyclic nucleotide 3 phosphodiesterase	tubulin, alpha 1a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Microtubule Plasma Membrane Microvillus Membrane Pseudopodium Myelin Sheath Abaxonal Region Myelin Sheath Adaxonal Region Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	RNA Binding 2',3'-cyclic-nucleotide 3'-phosphodiesterase Activity Cyclic Nucleotide Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding
	Biological Process	Microtubule Cytoskeleton Organization Synaptic Transmission Axonogenesis Aging Adult Locomotory Behavior Cyclic Nucleotide Catabolic Process Response To Toxic Substance Substantia Nigra Development Forebrain Development Response To Lipopolysaccharide Regulation Of Mitochondrial Membrane Permeability Oligodendrocyte Differentiation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MTNR1A PPP1CA PRKCD PRNP TUBA1A	53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		1267	7846
HPRD ID		00448	03959
Ensembl ID		ENSG00000173786	ENSG00000167552
Uniprot IDs		P09543	Q71U36
PDB IDs		1WOJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipid Catabolic Process Circadian Rhythm Interleukin-10 Production Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Filopodium Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Signal Transduction Interleukin-12 Production Negative Regulation Of Signaling Positive Regulation Of Ceramide Biosynthetic Process Cellular Response To Copper Ion Negative Regulation Of Calcium-mediated Signaling Regulation Of Ceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipid Transport Cellular Response To Stimulus Negative Regulation Of Platelet Aggregation Negative Regulation Of Interleukin-17 Production Positive Regulation Of Superoxide Anion Generation Regulation Of Glycogen Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell-cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of Cell Death Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Regulation Of Superoxide Anion Generation Response To Oxidative Stress Cell Division Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Positive Regulation Of CGMP Biosynthetic Process Regulation Of Cell Activation Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Response To External Stimulus Positive Regulation Of CGMP Metabolic Process Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation	Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration
Tagcloud ?		b blot caused culture e1 exposure gamma increases influence mc3t3 metabolism microm might moderate mrnas natriuretic northern npr osteoblastic peptide promotes rar retinoic retinoid retinoids rxr system unchanged x	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
Tagcloud (Difference) ?		b blot caused culture e1 exposure gamma increases influence mc3t3 metabolism microm might moderate mrnas natriuretic northern npr osteoblastic peptide promotes rar retinoic retinoid retinoids rxr system unchanged x	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
Tagcloud (Intersection) ?