NCKAP1 and SPP1

Number of citations of the paper that reports this interaction (PubMedID 22779921)
0

Data Source:
BioGRID (two hybrid)

		NCKAP1	SPP1
Description		NCK associated protein 1	secreted phosphoprotein 1
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GO Annotations	Cellular Component	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Vesicle Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding	Cytokine Activity Integrin Binding Protein Binding Small Molecule Binding Extracellular Matrix Binding
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Ossification Osteoblast Differentiation Androgen Catabolic Process Cell Adhesion Signal Transduction Embryo Implantation Cell Differentiation Biomineral Tissue Development Response To Vitamin D Response To Macrophage Colony-stimulating Factor Positive Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Estradiol Secretion
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Blood protein levels ( 30072576) Dental caries ( 23064961) Gout ( 33832965) Urate levels ( 31578528)
Interacting Genes		16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG	97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CIMIP5 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		10787	6696
HPRD ID		05353	01325
Ensembl ID		ENSG00000061676	ENSG00000118785
Uniprot IDs		A0A994J4I5 A0A994J6K9 Q9Y2A7	B7Z351 P10451 Q3LGB0
PDB IDs		3P8C 4N78 7USC 7USD 7USE	3CXD 3DSF 9EOU
Enriched GO Terms of Interacting Partners?		SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Cytosol Modulation Of Chemical Synaptic Transmission Wound Healing, Spreading Of Cells Regulation Of Ubiquitin-dependent Protein Catabolic Process Integrin Complex Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Biological Quality Microtubule Associated Complex Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Lamellipodium Membrane Regulation Of Proteolysis Extracellular Exosome Integrin-mediated Signaling Pathway Cell-matrix Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Integrin Alpha5-beta1 Complex Cell Adhesion Mediated By Integrin Integrin Alpha9-beta1 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta1 Complex Ribosomal Subunit TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Focal Adhesion Response To Stress Endodermal Cell Differentiation Developmental Process Negative Regulation Of Protein Catabolic Process Regulation Of System Process Protein Kinase CK2 Complex Alphav-beta3 Integrin-PKCalpha Complex Dendritic Microtubule Tail-anchored Membrane Protein Insertion Into ER Membrane Monoatomic Cation Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Calcium Channel Regulator Activity Metal Ion Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Synaptic Plasticity Regulation Of Protein Neddylation Biological_process Translation Dendritic Spine Cytosolic Ribosome Ruffle Membrane Cell-substrate Adhesion
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