NCKAP1

Gene Name		NCK-associated protein 1
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Gene Ontology Annotations	Cellular Component	Cytosol Focal Adhesion Integral Component Of Membrane SCAR Complex Lamellipodium Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Complex Binding Rac GTPase Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Involved In Gastrulation Innate Immune Response Basal Protein Localization Apical Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		11 interactors: ABI1 BRK1 CYFIP2 DNMBP GAS7 NCK1 RAC1 SPP1 WASF1 WASF2 YWHAG
Entrez ID		10787
HPRD ID		05353
Ensembl ID		ENSG00000061676
Uniprot IDs		Q9Y2A7
PDB IDs		3P8C
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Process Lamellipodium Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lamellipodium Assembly Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Rac Protein Signal Transduction Actin Filament Organization Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Defense Response Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Innate Immune Response Actin Filament Polymerization Regulation Of Immune Response Movement Of Cell Or Subcellular Component Lamellipodium Assembly Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Immune Response Regulation Of Immune System Process Organelle Organization Immune System Process Cellular Protein Complex Assembly Protein Polymerization Vesicle-mediated Transport Regulation Of Cell Projection Assembly Cell Projection Morphogenesis
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