NCKAP1 and NYAP1

Number of citations of the paper that reports this interaction (PubMedID 21946561)
80

Data Source:
BioGRID (pull down)

		NCKAP1	NYAP1
Description		NCK associated protein 1	neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse
	Molecular Function	Protein Binding Small GTPase Binding
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG	4 interacting genes: CYFIP1 NCKAP1 PIK3R1 TLN1
Entrez ID		10787	222950
HPRD ID		05353	13427
Ensembl ID		ENSG00000061676	ENSG00000166924
Uniprot IDs		A0A994J4I5 A0A994J6K9 Q9Y2A7	Q6ZVC0
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Ruffle Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation SCAR Complex Positive Regulation Of Actin Nucleation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Organization Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cortical Actin Cytoskeleton Organization Lamellipodium Assembly Regulation Of Actin Nucleation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Cortical Cytoskeleton Organization Lamellipodium Organization Focal Adhesion Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell-substrate Junction Organization Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Actin Filament Polymerization Regulation Of Cell-matrix Adhesion Regulation Of Cellular Component Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Paraxial Mesoderm Morphogenesis Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Lamellipodium Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Actin Filament Binding Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Translation At Postsynapse Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Component Organization Insulin Binding
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