CAP2 and ALAS1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CAP2	ALAS1
Name		cyclase associated actin cytoskeleton regulatory protein 2	5'-aminolevulinate synthase 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid
Pathways		Role of ABL in ROBO-SLIT signaling	Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs		None	Pyridoxal phosphate Pyridoxal phosphate Glycine
GWAS		Haemorrhoidal disease ( 33888516 ) Height ( 18391951 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 29213071 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 ) Parkinson's disease ( 28892059 ) Schizophrenia ( 23974872 )
Novel Interactors		1 novel interactors: DTNBP1	None recorded
Interacting Genes		11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE	54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		10486	211
HPRD ID		10808	00505
Ensembl ID		ENSG00000112186	ENSG00000023330
Uniprot IDs		B7Z385 E9PDI2 P40123	B4DVA0 P13196 Q5JAM2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Actin Monomer Binding