CAP2 and CAP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		CAP2	CAP1
Description		cyclase associated actin cytoskeleton regulatory protein 2	cyclase associated actin cytoskeleton regulatory protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane	Extracellular Region Cytoplasm Plasma Membrane Focal Adhesion Membrane Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding	Actin Binding Protein Binding Adenylate Cyclase Binding
	Biological Process	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Actin Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Role of ABL in ROBO-SLIT signaling	Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Haemorrhoidal disease ( 33888516) Height ( 18391951) Mitochondrial DNA levels ( 25240745) QT interval ( 29213071) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)	Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE	13 interacting genes: ACTB ACTG1 BARD1 CAP2 CEBPA CFTR FNDC3B LIG4 MYOC PLA2G4A SERPINB8 SNCA UCHL5
Entrez ID		10486	10487
HPRD ID		10808	09869
Ensembl ID		ENSG00000112186	ENSG00000131236
Uniprot IDs		B7Z385 E9PDI2 P40123	D3DPU2 Q01518
PDB IDs			1K8F
Enriched GO Terms of Interacting Partners?			Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Synaptic Vesicle Recycling Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Macrophage Activation Multicellular Organismal-level Homeostasis Cellular Response To Lithium Ion Postsynaptic Actin Cytoskeleton Organization Response To Lithium Ion Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Catabolic Process Regulation Of Organelle Organization NuA4 Histone Acetyltransferase Complex Apical Junction Complex Positive Regulation Of Macrophage Activation Maintenance Of Blood-brain Barrier Homeostatic Process Cellular Response To Metal Ion Anatomical Structure Homeostasis Tissue Homeostasis Kinesin Binding Platelet Aggregation Tau Protein Binding Regulation Of DNA Repair Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Vesicle-mediated Transport Basal Body Patch Negative Regulation Of MRNA 3'-end Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency Positive Regulation Of Organelle Organization Skeletal Muscle Hypertrophy Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Sulfite Oxidase Activity DNA Recombination Regulation Of Chromosome Organization
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