CAP2 and CFL2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CAP2	CFL2
Name		cyclase associated actin cytoskeleton regulatory protein 2	cofilin 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing
Pathways		Role of ABL in ROBO-SLIT signaling	None
Diseases		None	Nemaline myopathy
GWAS		Haemorrhoidal disease ( 33888516 ) Height ( 18391951 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 29213071 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 )	Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Atrial fibrillation ( 29892015 30061737 ) Hip circumference adjusted for BMI ( 28552196 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Takayasu arteritis ( 33308445 )
Novel Interactors		1 novel interactors: DTNBP1	2 novel interactors: LAIR1 ZYG11B
Interacting Genes		11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE	12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I
Entrez ID		10486	1073
HPRD ID		10808	03262
Ensembl ID		ENSG00000112186	ENSG00000165410
Uniprot IDs		B7Z385 E9PDI2 P40123	Q549N0 Q9Y281
PDB IDs		Not available	7M0G 7U8K
GO Terms Enriched among Interactors		None	Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization