EIF1B and SPG21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF1B	SPG21
Description		eukaryotic translation initiation factor 1B	SPG21 abhydrolase domain containing, maspardin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Eukaryotic 43S Preinitiation Complex	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosomal Small Subunit Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Refractive error ( 32231278)
Interacting Genes		7 interacting genes: ATXN1 DVL2 DVL3 GRSF1 PEX19 SPG21 TRIM38	161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629
Entrez ID		10289	51324
HPRD ID		17032	10492
Ensembl ID		ENSG00000114784	ENSG00000090487
Uniprot IDs		O60739 Q6FG85	Q9NZD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Non-canonical Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Peroxisome Membrane Targeting Sequence Binding Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Mitochondrial RNA Catabolic Process Peroxisome Membrane Biogenesis Regulation Of JNK Cascade POZ Domain Binding Cytoplasm Convergent Extension Involved In Organogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Convergent Extension Involved In Gastrulation Protein Import Into Peroxisome Membrane Locomotory Behavior Mitochondrial RNA Catabolic Process Membrane Biogenesis Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding Poly(G) Binding Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regionalization Cytosol Protein Stabilization Protein Targeting To Peroxisome Protein Carrier Chaperone Peroxisome Fission Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway CD4 Receptor Binding Convergent Extension Small GTPase Binding Ribonucleoprotein Granule Positive Regulation Of Viral Entry Into Host Cell Regulation Of Nucleobase-containing Compound Metabolic Process Segment Specification Negative Regulation Of Defense Response To Virus	Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?