EIF1B and GRSF1

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		EIF1B	GRSF1
Description		eukaryotic translation initiation factor 1B	G-rich RNA sequence binding factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Eukaryotic 43S Preinitiation Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosomal Small Subunit Binding	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing
Pathways			Viral mRNA Translation Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Type 2 diabetes ( 30718926)
Interacting Genes		7 interacting genes: ATXN1 DVL2 DVL3 GRSF1 PEX19 SPG21 TRIM38	55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3
Entrez ID		10289	2926
HPRD ID		17032	07276
Ensembl ID		ENSG00000114784	ENSG00000132463
Uniprot IDs		O60739 Q6FG85	Q12849
PDB IDs			2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Non-canonical Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Peroxisome Membrane Targeting Sequence Binding Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Mitochondrial RNA Catabolic Process Peroxisome Membrane Biogenesis Regulation Of JNK Cascade POZ Domain Binding Cytoplasm Convergent Extension Involved In Organogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Convergent Extension Involved In Gastrulation Protein Import Into Peroxisome Membrane Locomotory Behavior Mitochondrial RNA Catabolic Process Membrane Biogenesis Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding Poly(G) Binding Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regionalization Cytosol Protein Stabilization Protein Targeting To Peroxisome Protein Carrier Chaperone Peroxisome Fission Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway CD4 Receptor Binding Convergent Extension Small GTPase Binding Ribonucleoprotein Granule Positive Regulation Of Viral Entry Into Host Cell Regulation Of Nucleobase-containing Compound Metabolic Process Segment Specification Negative Regulation Of Defense Response To Virus	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development
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