Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
CDKN1B and YWHAQ
Number of citations of the paper that reports this interaction (PMID
12042314
)
63
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
CDKN1B
YWHAQ
Gene Name
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Phosphatase Binding
Hsp70 Protein Binding
Protein Complex Binding
Chaperone Binding
Protein Binding
Protein Domain Specific Binding
Protein N-terminus Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Response To Hypoxia
Potassium Ion Transport
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Glucose
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Positive Regulation Of Microtubule Polymerization
Response To Estradiol
Negative Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Phosphorylation
Response To Drug
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Response To Peptide Hormone
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Response To Cadmium Ion
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Cellular Component Movement
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Response To Organic Cyclic Compound
Mitotic Cell Cycle Arrest
Protein Targeting
Apoptotic Process
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Cellular Senescence
p53-Dependent G1/S DNA damage checkpoint
Cyclin E associated events during G1/S transition
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
G1/S Transition
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Signaling by PDGF
DAP12 interactions
DNA Damage/Telomere Stress Induced Senescence
GAB1 signalosome
Senescence-Associated Secretory Phenotype (SASP)
S Phase
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
SCF(Skp2)-mediated degradation of p27/p21
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
PI3K/AKT Signaling in Cancer
Adaptive Immune System
PIP3 activates AKT signaling
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
G1/S DNA Damage Checkpoints
Innate Immune System
Signalling by NGF
Synthesis of DNA
G1 Phase
Regulation of DNA replication
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell Cycle, Mitotic
Signaling by FGFR
Orc1 removal from chromatin
Cyclin D associated events in G1
Cell Cycle Checkpoints
Activation of BAD and translocation to mitochondria
Programmed Cell Death
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Systemic lupus erythematosus (
23273568
)
Heart rate variability traits (
22174390
)
Protein-Protein Interactions
62 interactors:
ABL1
AKT1
ARHGDIA
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COPS5
CUL1
CUL4A
GRB2
HIST1H1A
HIST1H1B
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
NUP50
PIN1
PSMB1
RCHY1
RNF123
RPS6KA1
SGK1
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
231 interactors:
AARS2
ABL1
ACSL4
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ATP5A1
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1L1
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HIST1H2BG
HIST2H4A
HNRNPA1
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
KCNK15
KCNK3
KCNK9
KIAA1429
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPC4
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSFA2
SSX2IP
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
Entrez ID
1027
10971
HPRD ID
02867
00886
Ensembl ID
ENSG00000111276
ENSG00000134308
Uniprot IDs
P46527
Q6I9V6
B4DMT8
P27348
PDB IDs
1H27
1JSU
2AST
2BTP
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Protein Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Cell Cycle Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Response To Organic Substance
Cell Communication
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Transferase Activity
Cellular Response To Stimulus
Positive Regulation Of Protein Modification Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Cellular Process
Cellular Protein Modification Process
Regulation Of Metabolic Process
Signal Transduction
Positive Regulation Of Cell Cycle
Signaling
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stimulus
Protein Catabolic Process
Apoptotic Process
Regulation Of Intracellular Transport
Programmed Cell Death
Viral Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Protein Localization
Cell Death
Death
Positive Regulation Of Intracellular Transport
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Organelle Organization
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Organelle Organization
Cellular Process
Cellular Response To Organic Substance
Regulation Of Cellular Component Organization
Response To Organic Substance
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Developmental Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Metabolic Process
Response To Stress
Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle Process
Death
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Protein Localization
Intracellular Signal Transduction
Apoptotic Process
Cell Cycle Process
Anatomical Structure Development
Cell Death
Regulation Of Cellular Localization
System Development
Multicellular Organismal Development
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Abiotic Stimulus
Positive Regulation Of Protein Metabolic Process
Intracellular Transport
Regulation Of Signaling
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Regulation Of Phosphorylation
Innate Immune Response
MRNA Metabolic Process
Cellular Localization
Immune System Process
Regulation Of Kinase Activity
Tagcloud
?
aggregated
anaplastic
atc
braf
cdkn2c
ctnnb1
eif1ax
exclusive
exome
harbored
hypermutator
landscape
mismatch
mlh
mlh1
mlh3
msh5
msh6
mutational
mutually
nf1
nf2
nras
ontology
pik3ca
ret
unresponsive
ush2a
v600e
Tagcloud (Difference)
?
aggregated
anaplastic
atc
braf
cdkn2c
ctnnb1
eif1ax
exclusive
exome
harbored
hypermutator
landscape
mismatch
mlh
mlh1
mlh3
msh5
msh6
mutational
mutually
nf1
nf2
nras
ontology
pik3ca
ret
unresponsive
ush2a
v600e
Tagcloud (Intersection)
?