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CDKN1B and YWHAH
Number of citations of the paper that reports this interaction (PubMedID
12042314
)
0
Data Source:
HPRD
(in vitro, in vivo)
CDKN1B
YWHAH
Description
cyclin dependent kinase inhibitor 1B
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Centrosome
Cytosol
Cilium
Cul4A-RING E3 Ubiquitin Ligase Complex
Ciliary Basal Body
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Intercalated Disc
Synapse
Extracellular Exosome
Presynapse
Glutamatergic Synapse
Cerebellar Granule Cell To Purkinje Cell Synapse
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin-dependent Protein Kinase Regulator Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein-folding Chaperone Binding
Molecular Adaptor Activity
Molecular Function Inhibitor Activity
Ubiquitin Ligase Activator Activity
Actin Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Sodium Channel Regulator Activity
Enzyme Binding
Protein Domain Specific Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Transmembrane Transporter Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Placenta Development
Potassium Ion Transport
Apoptotic Process
Regulation Of Exit From Mitosis
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Heart Development
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Programmed Cell Death
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA Replication
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Nuclear Export
Regulation Of Cell Cycle
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Senescence
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Cell Cycle G1/S Phase Transition
Epithelial Cell Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Sodium Ion Transport
Glucocorticoid Catabolic Process
Intracellular Protein Transport
Signal Transduction
Intracellular Protein Localization
Substantia Nigra Development
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Regulation Of Neuron Differentiation
Positive Regulation Of DNA-templated Transcription
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Membrane Depolarization During Action Potential
Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Phenethyl Isothiocyanate
Diseases
Prostate cancer
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
31562322
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
33272962
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Post bronchodilator FEV1 (
26634245
)
Type 2 diabetes (
30297969
)
Interacting Genes
70 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RCHY1
RNF123
RNF6
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2L3
UBE3A
UCHL1
WWP1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
69 interacting genes:
ABL1
ARHGEF28
BAD
BCR
BRAF
CCDC125
CDC25B
CDC25C
CDC42
CDK16
CDKN1B
CHRNA4
CREBBP
EPB41L2
EPB41L3
ESR1
ESR2
EXO1
GREM1
HSPB1
ILF3
ING1
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KLC3
KRT18
MAP3K3
MAP3K5
MARK4
MDM4
MED1
MST1R
NCAM2
NCOA1
NCOA2
NCOA3
NEDD4L
NEK1
NHSL2
NR3C1
NRIP1
PARD3
PARD6A
PARD6B
PCNT
PDPK1
PRKCI
PRKN
PTH1R
RAF1
REM1
RIMS1
RIMS2
RPH3A
SAMSN1
SNCA
SRC
THRA
TLX2
TNFAIP3
TPH1
TSC1
TSC2
YWHAE
YWHAG
ZFP36
Entrez ID
1027
7533
HPRD ID
02867
00215
Ensembl ID
ENSG00000111276
ENSG00000128245
Uniprot IDs
P46527
Q6I9V6
Q04917
Q9H4N8
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
7B5L
7B5M
7B5R
7OR8
7ORG
7ORH
7ORS
7ORT
8BYA
8BYL
8BZO
2C63
2C74
7NMZ
Enriched GO Terms of Interacting Partners
?
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Modification Process
Nucleus
Cell Cycle Phase Transition
Nucleoplasm
Modification-dependent Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cytosol
Post-translational Protein Modification
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Regulation Of Cell Cycle
Proteolysis
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Cellular Response To Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Catabolic Process
Protein Polyubiquitination
Protein Localization To Nucleus
Transferase Activity
NLS-dependent Protein Nuclear Import Complex
Regulation Of Macromolecule Metabolic Process
Protein Catabolic Process
Regulation Of Metabolic Process
Ubiquitin-protein Transferase Activity
NLS-bearing Protein Import Into Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Proteasomal Protein Catabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Regulation Of DNA Metabolic Process
Protein Import Into Nucleus
Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Ubiquitin Protein Ligase Binding
Protein Kinase Binding
Phosphoserine Residue Binding
Intracellular Signal Transduction
Nuclear Receptor-mediated Signaling Pathway
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Regulation Of Developmental Process
Regulation Of Biological Quality
PAR Polarity Complex
Regulation Of Intracellular Signal Transduction
Regulation Of Transport
Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Phosphorylation
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Regulation Of Vesicle-mediated Transport
Cell Junction Organization
Negative Regulation Of Apoptotic Process
Phosphorylation
Positive Regulation Of Metabolic Process
Enzyme Binding
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Multicellular Organismal Process
Response To Lipid
Cellular Response To Hormone Stimulus
Hormone-mediated Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Developmental Process
Positive Regulation Of Protein Localization
Protein Kinase Binding
Regulation Of Anatomical Structure Morphogenesis
Developmental Process
Cytoskeleton Organization
Cellular Response To Lipid
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Secretion By Cell
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Protein Serine/threonine Kinase Activity
Synaptic Vesicle Priming
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Protein Kinase Activity
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